F2-isoprostanes in kidney transplant patients:: Relationship with inflammatory markers
F2-isoprostanes in kidney transplant patients:: Relationship with inflammatory markers
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DOI：
10.1016/j.transproceed.2005.09.106
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发表时间：
2005-11-01
影响因子：
0.9
通讯作者：
Romero, R
中科院分区：
文献类型：
--
作者：
Lauzurica, R;Pastor, MC;Romero, R
这项前瞻性研究评估了一组透析患者在肾移植前和移植后3个月的炎症和氧化应激之间的关系，并将结果与对照组健康受试者进行了比较。测定的氧化应激标志物是不同的f2 -异前列腺素异构体。炎症标志物包括c反应蛋白、白细胞介素-6、肿瘤坏死因子-a和妊娠相关血浆蛋白a。43例患者为研究组，50例来自医院血库的健康受试者为对照组。结果显示，透析患者的炎症和氧化应激标志物水平高于对照组，尽管在肾移植后有所改善。最后，f2 -异前列腺素异构体与炎症标志物之间存在显著相关性。
This prospective study evaluated the relationship between inflammation and oxidative stress in a group of dialysis patients just before and 3 months after kidney transplantation and compared the results with a control group of healthy subjects. The oxidative stress markers determined were different F2-isoprostane isomers. The inflammatory markers included C-reactive protein, interleukin-6, tumor necrosis factor-a, and pregnancy-associated plasma protein A. Forty-three patients were the study group and 50 healthy subjects from a hospital blood bank as controls. The results showed levels of inflammatory and oxidative stress markers to be higher in the dialysis patients than in the control group, although they improved following kidney transplantation. Finally, significant correlations were observed between F2-isoprostane isomers and inflammatory markers.