Correlations between Epstein-Barr virus and acute leukemia
Correlations between Epstein-Barr virus and acute leukemia
复制标题
DOI：
10.1002/jmv.24797
复制
发表时间：
2017-08-01
影响因子：
12.7
通讯作者：
Luo, Bing
中科院分区：
文献类型：
--
作者：
Guan, Hongzai;Miao, Hongxia;Luo, Bing
EB 病毒 (EBV) 感染可能与急性白血病 (AL) 的发病有关。研究旨在探讨 EBV 感染与急性淋巴细胞白血病 (ALL) 免疫表型和染色体畸变之间的关系。此外，还描述了 EBV 对临床预后的影响。采用荧光定量聚合酶链反应（FQ-PCR）检测110例ALL患者、75例急性髓系白血病（AML）患者和37例血液学健康对照受试者的骨髓中EBV-DNA拷贝数。在 185 名 AL 患者中的 64 名 (34.6%) 和 37 名健康对照受试者中的 2 名中发现了 EBV-DNA 拷贝 (P < 0.001)。 ALL患者、AML患者和健康对照者的EBV感染率分别为40.9%（45/110）、25.3%（19/75）和5.4%（2/37）。 ALL和AML组EBV阳性率高于健康组（P < 0.05）。 12 例 T-ALL 中有 1 例（8.3%）检测到 EBV-DNA 拷贝，98 例 B-ALL 中有 44 例（44.9%）检测到 EBV-DNA 拷贝，B-ALL 中 EBV 阳性率较 T-ALL 显着升高（P < 0.05）。染色体核型分析显示，染色体异常的B-ALL、T-ALL、AML患者EBV感染率分别为46.3%（25/54）、33.3%（1/3）、30%（9/30）。染色体异常与EBV感染之间差异无统计学意义（P>0.05）。此外，EBV+-ALL 的复发率和死亡率高于 EBV--ALL。综上所述，EBV感染可能与AL的发生相关，且B-ALL中EBV的感染率高于T-ALL。 EBV阳性患者预后不良。
Infection with Epstein-Barr virus (EBV) may be correlated to the onset of acute leukemia (AL). Studies were performed to investigate the relationship between EBV infection and immunophenotyping of acute lymphoblastic leukemia (ALL) and chromosome aberrations. Additionally, the effects of EBV on clinical prognosis were described. Fluorescence quantitative polymerase chain reaction (FQ-PCR) was used to detect EBV-DNA copy numbers from bone marrow in 110 cases of patients with ALL, 75 cases of patients with acute myeloid leukemia (AML), and 37 cases of hematologically healthy control subjects. EBV-DNA copies were found in 64 of 185 (34.6%) patients with AL and 2 of 37 healthy control subjects (P < 0.001). The EBV infection rate of ALL patients, AML patients, and healthy controls was 40.9% (45/110), 25.3% (19/75), and 5.4% (2/37), respectively. The positive rate of EBV in the ALL and AML groups was higher than in healthy subjects (P < 0.05). EBV-DNA copies were found in 1 of 12 (8.3%) T-ALLs and 44 of 98 (44.9%) B-ALLs, the positive rate of EBV in B-ALLs increased significantly compared to the rate of T-ALLs (P < 0.05). Chromosome karyotype analysis showed that EBV infection rates in B-ALL, T-ALL, and AML patients with chromosome abnormalities were 46.3% (25/54), 33.3% (1/3), and 30% (9/30), respectively. There was no statistical significance between chromosome abnormality and EBV infection (P > 0.05). In addition, EBV+-ALLs had higher relapse and mortality rates than that of EBV--ALLs. Together, we conclude that EBV infection may be correlated with the incidence of AL, and the infection rate of EBV in B-ALL was higher than that of T-ALL. EBV-positive patients showed an unfavorable prognosis.