Attacking the supply wagons to starve cancer cells to death.
Attacking the supply wagons to starve cancer cells to death.
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DOI：
10.1002/1873-3468.12121
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发表时间：
2016-04
期刊：
影响因子：
3.5
通讯作者：
Edinger AL
中科院分区：
文献类型：
--
作者：
Selwan EM;Finicle BT;Kim SM;Edinger AL
The constitutive anabolism of cancer cells supports proliferation but also addicts tumor cells to a steady influx of exogenous nutrients. Limiting access to metabolic substrates could be an effective and selective means to block cancer growth. In this review, we define the pathways by which cancer cells acquire the raw materials for anabolism, highlight the actionable proteins in each pathway, and discuss the status of therapeutic interventions that disrupt nutrient acquisition. Critical open questions to be answered before apical metabolic inhibitors can be successfully and safely deployed in the clinic are also outlined. In summary, recent studies provide strong support that substrate limitation is a powerful therapeutic strategy to effectively, and safely, starve cancer cells to death.
