A gravity-based three-dimensional compass in the mouse brain
A gravity-based three-dimensional compass in the mouse brain
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DOI：
10.1038/s41467-020-15566-5
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发表时间：
2020-04-15
影响因子：
16.6
通讯作者：
Laurens, Jean
中科院分区：
文献类型：
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作者：
Angelaki, Dora E.;Ng, Julia;Laurens, Jean
重力传感为三维导航提供了强大的垂直度信号。哺乳动物边缘系统中的头部方向细胞实现了一个异中心神经元罗盘。在这里，我们表明，头部方向细胞在啮齿动物丘脑，压后皮质和扣带纤维束被调谐到方位角和倾斜，即俯仰或滚动的结合组合。俯仰和滚转方向调整锚定到重力和独立的视觉地标。当头部倾斜时，方位角调谐被固定到头部水平面，但也使用重力来保持锚定到地球水平面中的非同心轴承。总的来说，这些结果表明，一个三维的，基于重力的，神经罗盘可能是哺乳动物物种，包括地面动物的普遍属性。
Gravity sensing provides a robust verticality signal for three-dimensional navigation. Head direction cells in the mammalian limbic system implement an allocentric neuronal compass. Here we show that head-direction cells in the rodent thalamus, retrosplenial cortex and cingulum fiber bundle are tuned to conjunctive combinations of azimuth and tilt, i.e. pitch or roll. Pitch and roll orientation tuning is anchored to gravity and independent of visual landmarks. When the head tilts, azimuth tuning is affixed to the head-horizontal plane, but also uses gravity to remain anchored to the allocentric bearings in the earth-horizontal plane. Collectively, these results demonstrate that a three-dimensional, gravity-based, neural compass is likely a ubiquitous property of mammalian species, including ground-dwelling animals.