Recreational physical activity and survival among young women with breast cancer
Recreational physical activity and survival among young women with breast cancer
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DOI：
10.1002/cncr.22201
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发表时间：
2006-10-15
期刊：
影响因子：
6.2
通讯作者：
Coates, Ralph J.
中科院分区：
文献类型：
--
作者：
Abrahamson, Page E.;Gammon, Marilie D.;Coates, Ralph J.
背景大多数流行病学研究报告，降低患乳腺癌的风险与较高水平的娱乐性体育活动有关，但很少有人知道它对乳腺癌的影响。在这项研究中，作者调查了在诊断前进行的活动是否会影响基于人群的队列中的乳腺癌生存率。在1990年至1992年期间，对1264名年龄在20至54岁之间被诊断为浸润性乳腺癌的妇女进行了随访研究。研究中的女性在诊断后的几个月内接受了采访，并被问及她们在13岁，20岁和诊断前一年的中度和剧烈活动的平均频率。随访8 - 10年，使用国家死亡指数（n = 290例死亡）确定全因死亡率状态。与最低四分位数相比，诊断前一年活动量最高的四分位数的风险比（HR）略有降低（阶段调整和收入调整的HR，0.78; 95%置信区间[95%CI]，0.56-1.08）。在诊断时超重或肥胖的女性中，高活动与HR降低相关（HR，0.70; 95%CI，0.49-0.99），但在理想体重或体重不足的女性中则无关（HR，1.08; 95%CI，0.77-1.52）。在13岁或20岁时的活动或在3个研究时期的平均活动中，HR降低并不明显。这项研究的结果提供了一些提示性证据，表明在诊断前一年进行的娱乐性体育活动对生存有有益影响，特别是在诊断时超重或肥胖的女性中。2006年由美国癌症协会出版。
BACKGROUND. Most epidemiologic studies report a reduced risk of developing breast cancer associated with higher levels of recreational physical activity, but little is known regarding its effect on prognosis.METHODS. in this study, the authors investigated whether activity undertaken prior to diagnosis influenced breast cancer survival in a population-based cohort. A follow-up study was conducted among 1264 women ages 20 to 54 years who were diagnosed with invasive breast cancer between 1990 and 1992. Women in the study were interviewed within several months of diagnosis and were asked about their average frequency of moderate and vigorous activity at age 13 years, age 20 years, and during the year before diagnosis. With 8 to 10 years of follow-up, all-cause mortality status was determined by using the National Death Index (n = 290 deaths).RESULTS. A modest reduction in the hazards ratio (HR) was observed for the highest quartile of activity in the year before diagnosis compared with the lowest quartile (stage-adjusted and income-adjusted HR, 0.78; 95% confidence interval [95% CI], 0.56-1.08). High activity was associated with a reduced HR among women who were overweight or obese at the time of diagnosis (HR, 0.70; 95% CI, 0.49-0.99) but not among ideal weight or underweight women (HR, 1.08; 95% CI, 0.77-1.52). A reduced HR was not evident for activity at age 13 years or 20 years or for average activity across the 3 periods studied.CONCLUSIONS. The results of this study provided some suggestive evidence for a beneficial effect on survival of recreational physical activity undertaken in the year before diagnosis, particularly among women who are over-weight or obese near the time of diagnosis. Published 2006 by the American Cancer Society.