Patterns of growth among children who later develop type 2 diabetes or its risk factors
Patterns of growth among children who later develop type 2 diabetes or its risk factors
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DOI：
10.1007/s00125-006-0459-1
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发表时间：
2006-12-01
期刊：
影响因子：
8.2
通讯作者：
Barker, D. J. P.
中科院分区：
文献类型：
--
作者：
Eriksson, J. G.;Osmond, C.;Barker, D. J. P.
我们研究了胎儿和儿童的生长模式与成人生活中的IGT和2型糖尿病相关。我们对1934年至1944年间出生在赫尔辛基的2003名受试者进行了临床检查。他们在出生到两岁之间平均测量了11次身高和体重，在2岁到11岁之间平均测量了7次。通过75克口服葡萄糖耐量试验评估成人生活中的葡萄糖耐量。我们确定了311名2型糖尿病患者和496名IGT患者。IGT和2型糖尿病均与低出生体重相关（p < 0.0001）。出生到两岁之间体重增加过少会增加患这些疾病的风险。2年体重增加1 SD与2型糖尿病或IGT的比值比为0.76相关（95% CI 0.69-0.84）。这种影响在出生体重低的人身上表现得最为明显。出生后6个月的低生长是日后胰岛素抵抗发展的关键时期；其他关键时期与胎儿生长缓慢和2岁至11岁之间的体重指数迅速增加有关。婴儿时期体重增加少会增加IGT和2型糖尿病的风险。这种影响在出生体重较低的人身上更为明显。出生后的前6个月可能是生长最关键的时期，与葡萄糖耐受不良的发展有关。
We studied fetal and childhood growth patterns that are associated with IGT and type 2 diabetes in adult life.We examined clinically 2,003 subjects born in Helsinki between 1934 and 1944. They had on average 11 measurements of height and weight between birth and 2 years of age, and seven measurements between 2 and 11 years of age. Glucose tolerance in adult life was assessed by a 75-g oral glucose tolerance test.We identified 311 subjects with type 2 diabetes and 496 with IGT. Both IGT and type 2 diabetes were associated with low birthweight (p < 0.0001 adjusting for current BMI). The risk of these conditions was increased by low weight gain between birth and 2 years. A 1 SD increase in weight at 2 years was associated with an odds ratio for either type 2 diabetes or IGT of 0.76 (95% CI 0.69-0.84). This effect was greatest in people who had low birthweight. Low growth in the first 6 months after birth was a critical period for the development of insulin resistance in later life; other critical periods were associated with slow fetal growth and rapid increase in BMI between age 2 and 11 years.Low weight gain during infancy increases the risk of IGT and type 2 diabetes. The effect is greater in people who had low birthweight. The first 6 months after birth may be the most critical period for growth, in relation to development of glucose intolerance.