Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer
Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer
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下调真核翻译起始因子3b抑制胃癌增殖和转移
DOI：
10.1038/s41419-019-1846-0
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发表时间：
2019-08-19
影响因子：
9
通讯作者：
Li, Wenjuan
中科院分区：
文献类型：
--
作者：
Ma, Fang;Li, Xue;Li, Wenjuan
真核细胞翻译起始因子3（eIF3）在mRNA翻译、细胞生长和肿瘤发生发展中起重要作用。eIF3b是eIF3复合物中的主要支架亚基，并已被证明有助于几种癌症的发展。首先，我们的研究发现下调eIF3b可以通过调节肿瘤相关基因的表达来抑制胃癌细胞的增殖和转移。此外，eIF3b的表达与胃癌的分期和进展相关，并且与eIF3b在正常胃组织中的表达相比，在人慢性胃炎和胃癌组织中显示出上调。幽门螺杆菌（H. pylori）感染可上调胃癌细胞eIF3b的表达，提示eIF3b可能参与了H.幽门。上述发现确定了eIF3b在胃癌发生中的致癌作用，这可能有助于探索和发现胃癌治疗的新靶点。
Eukaryotic translation initiation factor 3 (eIF3) plays an important role in the regulation of mRNA translation, cell growth and cancer development. eIF3b is the main scaffolding subunit in the eIF3 complex and has been demonstrated to contribute to the development of several cancers. First, our study found that the downregulation of eIF3b could inhibit the proliferation and metastasis of gastric cancer cells by regulating the expression of cancer-related genes. In addition, the expression of eIF3b correlated with the stage and progression of gastric cancer and was shown to be upregulated in human chronic gastritis and in gastric cancer tissues compared with the expression of eIF3b in normal gastric tissues. Moreover,Helicobacter pylori(H. pylori) infection could upregulate the expression of eIF3b in gastric cancer cells, suggesting that eIF3b might be involved in the carcinogenic process ofH. pylori. The above findings identified the oncogenic role of eIF3b in gastric cancer development, and this may contribute to the exploration and discovery of novel therapeutic targets for gastric cancer treatment.