The Brain's Orienting Response: An Event-Related Functional Magnetic Resonance Imaging Investigation
The Brain's Orienting Response: An Event-Related Functional Magnetic Resonance Imaging Investigation
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DOI：
10.1002/hbm.20587
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发表时间：
2009-04-01
影响因子：
4.8
通讯作者：
Brown, Truman R.
中科院分区：
文献类型：
--
作者：
Friedman, David;Goldman, Robin;Brown, Truman R.
大脑的定向反应的一个重要功能是能够评估新的环境事件，以便为潜在的行为行动做准备。在这里，我们使用意外（即，小说）环境声音的背景下提出的听觉新奇古怪的范例。在对新奇古怪的人的ERP研究中，重复相同的新奇声音会导致新奇P3的习惯化，这是定向反应的ERP标志。重复也会导致后续积极性的增强，这似乎反映了环境声音的语义分析。在这种适应erfMRI记录，频繁的音调随机混合与不常见的目标音调和同样罕见的新的，环境的声音。受试者通过快速按下按钮来响应目标。为了评估习惯，一些环境声音在最初呈现后重复了两个街区。正如预期的那样，新的声音和目标音调导致了广泛的激活，但有些不同，神经网络。然而，与预期相反的是，没有显着的领域，其中激活减少，以响应第二次相比，第一次介绍的新的声音。相反，新的声音相对于目标音调产生的活动在额下回（BA 45）与这些事件的语义分析一致。我们的结论是，一个关键的伴随的定向反应是提取的意义，从而使一个确定的环境扰动的意义，并采取适当的目标导向的行动。《脑地图》30：1144 - 1154，2009年。(C)2008 Wiley-Liss，Inc.
An important function of the brain's orienting response is to enable the evaluation of novel, environmental events in order to prepare for potential behavioral action. Here, we assessed the event-related hemodynamic (erfMRI) correlates of this phenomenon using unexpected (i.e., novel) environmental sounds presented within the context of an auditory novelty oddball paradigm. In ERP investigations of the novelty oddball, repetition of the identical novel sound leads to habituation of the novelty P3, an ERP sign of the orienting response. Repetition also leads to an enhancement of a Subsequent positivity that appears to reflect semantic analysis of the environmental Sounds. In this adaptation for erfMRI recording, frequent tones were intermixed randomly with infrequent target tones and equally infrequent novel, environmental sounds. Subjects responded via speeded button press to targets. To assess habituation, some of the environmental sounds were repeated two blocks after their initial presentation. As expected, novel Sounds and target tones led to activation of widespread, but somewhat different, neural networks. Contrary to expectation, however, there were no significant areas in which activation was reduced in response to second compared to first presentations of the novel sounds. Conversely, novel sounds relative to target tones engendered activity in the inferior frontal gyrus (BA 45) consistent with semantic analysis of these events. We conclude that a key concomitant of the orienting response is the extraction of meaning, thereby enabling one to determine the significance of the environmental perturbation and take appropriate goal-directed action. Hum Brain Mapp 30:1144-1154, 2009. (C) 2008 Wiley-Liss, Inc.