Neuroimaging studies of autobiographical event memory
Neuroimaging studies of autobiographical event memory
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DOI：
10.1098/rstb.2001.0944
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发表时间：
2001-09-29
影响因子：
6.3
通讯作者：
Maguire, EA
中科院分区：
文献类型：
--
作者：
Maguire, EA
自传体事件记忆的神经影像学研究结果的共性和差异进行了审查。一般而言，跨研究的总体模式是与自传体事件记忆的提取相关的内侧和左侧激活。似乎内侧额叶皮层和左侧海马体对这些记忆特别敏感。然而，研究之间也存在不一致之处，例如海马体和背外侧前额叶皮层的激活。研究之间的方法差异可能导致不同的结果。量化和评估自传体事件记忆在许多领域都是一个挑战，包括神经影像学。可能与神经影像学数据的解释和未来实验的设计有关的方法学因素进行了讨论。还考虑到功能性神经影像学可能唯一倾向于检查的记忆方面。这些包括评估患者受损组织的功能以及估计相关脑区之间的区域间通信（有效连接）。
Commonalities and differences in findings across neuroimaging studies of autobiographical event memory are reviewed. In general terms, the overall pattern across studies is of medial and left-lateralized activations associated with retrieval of autobiographical event memories. It seems that the medial frontal cortex and left hippocampus in particular are responsive to such memories. However, there are also inconsistencies across studies, for example in the activation of the hippocampus and dorsolateral prefrontal cortex. It is likely that methodological differences between studies contribute to the disparate findings. Quantifying and assessing autobiographical event memories presents a challenge in many domains, including neuroimaging. Methodological factors that may be pertinent to the interpretation of the neuroimaging data and the design of future experiments are discussed. Consideration is also given to aspects of memory that functional neuroimaging might be uniquely disposed to examine. These include assessing the functionality of damaged tissue in patients and the estimation of inter-regional communication (effective connectivity) between relevant brain regions.