Lack of correlation between heparin dose and standard clinical monitoring tests in treatment with unfractionated heparin in critically III children
Lack of correlation between heparin dose and standard clinical monitoring tests in treatment with unfractionated heparin in critically III children
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DOI：
10.3324/haematol.10696
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发表时间：
2007-04-01
期刊：
影响因子：
10.1
通讯作者：
Mitchell, Lesley G.
中科院分区：
文献类型：
--
作者：
Kuhle, Stefan;Eulmesekian, Pablo;Mitchell, Lesley G.
The activated partial thromboplastin time (aPTT) and anti-Xa activity are used for monitoring unfractionated heparin (UFH) therapy in children and may not be optimal. Objective: Determine correlations of aPTT, anti-Xa and UFH dose in children. Single centre prospective cohort study in children receiving UFH. The aPTT and anti-Xa results from routine coagulation monitoring were collected. Thirty-nine children (median age 18 days) were enrolled. There was no relationship between aPTT and UFH dose (r(2)=0.12) or anti-Xa and UFH dose (r(2)=0.03) or aPTT and anti-Xa (r(2)=0.22). aPTT and anti-Xa do not accurately monitor UFH therapy in children.
