The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.
The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.
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DOI：
10.1016/j.devcel.2017.04.001
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发表时间：
2017-05-08
影响因子：
11.8
通讯作者：
Kopan R
中科院分区：
文献类型：
--
作者：
Kovall RA;Gebelein B;Sprinzak D;Kopan R
Notch信号传导途径依赖于蛋白水解级联以释放其转录活性的细胞内结构域，依赖于展开保护结构域并允许蛋白水解的力，依赖于细胞外结构域糖基化以调节由内吞配体施加的力，以及依赖于核蛋白、染色质修饰剂、泛素连接酶和一些激酶的杂七杂八的组合以调节活性和半衰期。在这里，我们提供了一个审查最近的分子见解Notch信号是如何触发和细胞形状如何影响这些事件，并使用新的见解来阐明一些令人困惑的观察。
The Notch signaling pathway relies on a proteolytic cascade to release its transcriptionally active intracellular domain, on force to unfold a protective domain and permit proteolysis, on extracellular domain glycosylation to tune the forces exerted by endocytosed ligands, and on a motley crew of nuclear proteins, chromatin modifiers, ubiquitin ligases, and a few kinases to regulate activity and half-life. Herein we provide a review of recent molecular insights into how Notch signals are triggered and how cell shape affects these events, and use the new insights to illuminate a few perplexing observations.