t(6; 11) renal cell carcinoma. A case report successfully diagnosed by using fluorescence in situ hybridization.
t(6; 11) renal cell carcinoma. A case report successfully diagnosed by using fluorescence in situ hybridization.
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DOI：
10.1002/iju5.12353
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发表时间：
2021-11
期刊：
影响因子：
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通讯作者：
Kamba T
中科院分区：
文献类型：
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作者：
Nishizawa H;Baba M;Furuya M;Kato I;Kurahashi R;Honda Y;Mikami Y;Nagashima Y;Eto M;Kamba T
易位性肾细胞癌的诊断具有挑战性。我们在此报告一例易位（6;11）肾细胞癌，经荧光原位杂交成功诊断。在一名21岁克罗恩病男性患者的随访期间，计算机断层扫描显示右肾有一个40 mm的肿块。由于影像学检查不能排除恶性肿瘤，因此进行了穿刺活检。活检标本的组织学诊断为肾细胞癌，但组织学分型尚未充分完成。然后进行腹腔镜肾部分切除术。转录因子EB免疫反应阳性，断裂和融合荧光原位杂交显示转录因子EB重排。结果，作出了t（6; 11）肾细胞癌的明确诊断。5年来没有复发。转录因子EB免疫组化和荧光原位杂交是诊断年轻一代肾肿瘤的有用工具。
Definitive diagnosis of translocation renal cell carcinoma is challenging. We herein experienced a case of translocation(6;11) renal cell carcinoma, successfully diagnosed by using fluorescence in situ hybridization. During the follow‐up of a 21‐year‐old man with Crohn's disease, computed tomography revealed a 40‐mm mass in the right kidney. Since imaging could not exclude malignancy, needle biopsy was performed. The histological diagnosis from the biopsy specimen was renal cell carcinoma, but histological typing had not been done adequately. A laparoscopic partial nephrectomy was then performed. Transcription factor EB immunoreactivity was positive, transcription factor EB rearrangement was shown by break apart and fusion fluorescence in situ hybridization. As a result, a definitive diagnosis of t(6; 11) renal cell carcinoma was made. There has been no recurrence for 5 years. Transcription factor EB immunohistochemistry and fluorescence in situ hybridization are useful diagnostic tools for renal tumors of young generation.