The role of attenuated redox and heat shock protein responses in the age-related decline in skeletal muscle mass and function.
The role of attenuated redox and heat shock protein responses in the age-related decline in skeletal muscle mass and function.
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DOI：
10.1042/ebc20160088
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发表时间：
2017-07
影响因子：
6.4
通讯作者：
A. Mcardle;M. Jackson
中科院分区：
文献类型：
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作者：
A. Mcardle;M. Jackson
随着年龄的增长，肌肉质量的损失和虚弱是老年人身体虚弱和失去独立性的主要原因。随着年龄的增长和氧化还原调节过程的破坏，肌肉无法适应生理应激（如运动），并且应激反应被认为在这些缺陷中起重要作用。氧化还原调节在控制特定应激反应中的作用，包括肌肉产生热休克蛋白（HSP），似乎特别重要，并受衰老的影响。在氧化还原和HSP反应被修饰的实验模型中的转基因和敲除研究已经证明了这些过程在衰老期间维持肌肉质量和功能的重要性。新的数据还表明，这些过程有可能与其他组织的衰老相互作用并影响其他组织的衰老。特别是氧化还原信号传导和热休克蛋白在炎症通路的调节中的作用在其对生物体衰老的影响中显得重要。这篇综述将简要地指出这一领域的重要性，并展示如何理解氧化还原和应激反应相互作用的方式，以及它们如何被控制提供了相当大的希望，作为一种方法，以改善骨骼肌（和潜在的其他组织）老化的主要功能后果的人。
The loss of muscle mass and weakness that accompanies ageing is a major contributor to physical frailty and loss of independence in older people. A failure of muscle to adapt to physiological stresses such as exercise is seen with ageing and disruption of redox regulated processes and stress responses are recognized to play important roles in theses deficits. The role of redox regulation in control of specific stress responses, including the generation of heat shock proteins (HSPs) by muscle appears to be particularly important and affected by ageing. Transgenic and knockout studies in experimental models in which redox and HSP responses were modified have demonstrated the importance of these processes in maintenance of muscle mass and function during ageing. New data also indicate the potential of these processes to interact with and influence ageing in other tissues. In particular the roles of redox signalling and HSPs in regulation of inflammatory pathways appears important in their impact on organismal ageing. This review will briefly indicate the importance of this area and demonstrate how an understanding of the manner in which redox and stress responses interact and how they may be controlled offers considerable promise as an approach to ameliorate the major functional consequences of ageing of skeletal muscle (and potentially other tissues) in man.