Dietary retinol: prevention or promotion of carcinogenesis in humans?
Dietary retinol: prevention or promotion of carcinogenesis in humans?
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膳食视黄醇：预防或促进人类致癌？
DOI：
10.1007/bf00054305
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Zheng,TZ
中科院分区：
文献类型：
--
作者：
Mayne,ST;Graham,S;Zheng,TZ
许多流行病学研究发现，“维生素A”与降低人类癌症风险有关。膳食维生素A指数反映了饮食中几种化合物的摄入量，包括视黄醇和维生素A原类胡萝卜素，如β-胡萝卜素，最近的癌症流行病学研究试图区分视黄醇和β-胡萝卜素的影响。虽然β-胡萝卜素一直与降低许多人类癌症，特别是上皮性癌症的风险有关，但视黄醇通常被发现与许多癌症的风险无关，或正相关。在许多研究中，特别是食道癌、口腔癌、咽喉癌、胃癌、结肠癌和直肠癌的研究中，已经观察到明显的癌变增强。虽然这一发现可能是人为的，但动物实验研究以及机制考虑表明，这种影响值得认真考虑。正如本文所讨论的，致癌作用的明显增强可能与乙醇/视黄醇相互作用有关，和/或涉及视黄醇的促氧化活性而β-胡萝卜素的抗氧化活性的机制有关。本文最后提出了进一步研究的建议，以帮助阐明视黄醇与人类癌变之间的关系。
A number of epidemiologic studies have found that ‘vitamin A’ is associated with a reduced risk for human cancers. Dietary vitamin A indices reflect intake of several compounds in the diet including retinol and provitamin A carotenoids such as β-carotene, and recent cancer epidemiology studies have attempted to distinguish effects of retinol from those of β-carotene. While β-carotene has been associated consistently with a reduced risk for a number of human cancers, particularly epithelial cancers, retinol is generally found to be unassociated with, or positively associated with, risk for many cancers. An apparent enhancement of carcinogenesis has been observed in numerous studies, particularly of cancer of the esophagus, oral cavity, pharynx, larynx, stomach, colon, and rectum. While this finding could be artifactual, experimental studies in animals as well as mechanistic considerations suggest that this effect deserves serious consideration. As discussed in this article, an apparent enhancement of carcinogenesis could be related to an ethanol/retinol interaction, and/or a mechanism involving pro-oxidant activity of retinol but anti-oxidant activity of β-carotene. This article concludes with suggestions for further research to help clarify the association between retinol and human carcinogenesis.