Fat mass is not beneficial to bone in adolescents and young adults
Fat mass is not beneficial to bone in adolescents and young adults
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DOI：
10.1210/jc.2006-0794
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发表时间：
2007-01-01
影响因子：
5.8
通讯作者：
Gilsanz, Vicente
中科院分区：
文献类型：
--
作者：
Janicka, Agnieszka;Wren, Tishya A. L.;Gilsanz, Vicente
内容：虽然肌肉质量对骨骼有益，但脂肪质量对骨骼影响的研究产生了相互矛盾的结果。目的：本研究的目的是评估瘦体重和脂肪质量与骨骼结构之间的关系。设计：本研究是横断面研究。设置：本研究在一般社区进行。受试者：受试者包括300名健康的性成熟青少年和年轻人（150名男性和150名女性）年龄在13岁和21岁之间。主要结果测量：我们研究了双能X射线吸收测定法（DXA）测量全身脂肪和瘦体重与DXA获得的骨骼值之间的关系（腿部和腰椎骨密度和骨矿物质含量）和计算机断层扫描（CT）（股骨的横截面积和皮质骨面积以及椎骨的横截面积和松质骨密度）。一元和多元线性回归分析显示，DXA瘦体重与中轴骨和中轴骨的所有CT和DXA测量值均呈显著正相关（均P < 0.005）。相比之下，虽然脂肪量和骨骼参数的DXA测量值之间的Pearson相关性通常为正，但多元回归分析显示，脂肪量在考虑瘦体重、躯干高度/腿长后，与骨骼的CT和DXA值呈负相关或不相关。我们的研究结果提供了令人信服的证据，尽管增加了机械负荷和独立的瘦体重，脂肪组织是不利于骨结构。
Context: Although muscle mass is beneficial to bone, studies on the effect of fat mass on bone have yielded conflicting results.Objective: The aim of this study was to assess the relations between lean and fat mass and bone structure.Design: This study was cross-sectional.Setting: The study was conducted in a general community.Subjects: Subjects included 300 healthy sexually mature adolescents and young adults (150 males and 150 females) between the ages of 13 and 21 yr.Main Outcome Measure: We investigated the relation between dual-energy x-ray absorptiometry (DXA) measures of total body fat and lean mass and bone values obtained with DXA (legs and lumbar spine bone mineral density and bone mineral content) and computed tomography (CT) (cross-sectional and cortical bone areas of the femurs and cross-sectional area and cancellous bone density of the vertebrae).Results: Simple and multiple linear regression analyses showed significant positive relations between DXA lean mass and all CT and DXA measures of bone in the axial and appendicular skeletons (all P < 0.005). In contrast, whereas Pearson correlations between DXA measures of fat mass and bone parameters were generally positive, multiple regression analyses showed that fat mass, after accounting for lean mass, trunk height/leg length, had a negative, or no, correlation with CT and DXA values for bone.Conclusions: Our findings provide compelling evidence that, despite increased mechanical loading and independent of lean mass, adipose tissue is not beneficial to bone structure.