HYPOTENSIVE ACTIVITY OF FIBROBLAST GROWTH-FACTOR
HYPOTENSIVE ACTIVITY OF FIBROBLAST GROWTH-FACTOR
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DOI：
10.1126/science.1957172
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发表时间：
1991-11-22
期刊：
影响因子：
56.9
通讯作者：
GIMENEZGALLEGO, G
中科院分区：
文献类型：
--
作者：
CUEVAS, P;CARCELLER, F;GIMENEZGALLEGO, G
酸性和碱性成纤维细胞生长因子（FGF）是广谱有丝分裂原蛋白质家族的成员，具有不同的细胞因子样活性，并且在肿瘤发生中起作用。FGF升高细胞内钙离子浓度的能力表明FGF可诱导内皮源性舒张因子（EDRF）的合成，从而舒张血管。全身给予FGF可降低动脉血压。这种作用是由EDRF和腺苷三磷酸敏感性钾离子通道介导的。通过蛋白质工程将FGF的促增殖作用与其促有丝分裂活性分离。这些结果扩展了FGF自分泌活性和潜在治疗应用的范围，强调了内皮作为动脉血压调节器官的作用，并提供了对FGF功能结构基础的见解。
Acidic and basic fibroblast growth factors (FGFs) are members of a family of proteins that are broad-spectrum mitogens, have diverse hormone-like activities, and function in tumorigenesis. FGF's ability to raise the concentration of intracellular calcium ion suggests that FGF could induce the synthesis of endothelium-derived relaxing factor (EDRF) and consequently vasodilation. Systemic administration of FGF decreased arterial blood pressure. This effect was mediated by EDRF and by adenosine triphosphate-sensitive potassium ion channels. The hypotensive effect of FGF was segregated from its mitogenic activity by protein engineering. These results extend the range of FGF autocrine activities and potential therapeutic applications, emphasize the role of endothelium as an arterial blood pressure-regulating organ, and provide insight on the structural basis of FGF functions.