Reduced volume of parietal and frontal association areas in patients with schizophrenia characterized by passivity delusions
Reduced volume of parietal and frontal association areas in patients with schizophrenia characterized by passivity delusions
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DOI：
10.1017/s0033291704003113
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发表时间：
2005-06-01
影响因子：
6.9
通讯作者：
Pantelis, C
中科院分区：
文献类型：
--
作者：
Maruff, P;Wood, SJ;Pantelis, C
背景。在精神分裂症患者中，被动性妄想的特点是难以确定有目的的行为的作用。神经心理学和功能性神经影像学数据表明，被动妄想与顶叶联合皮质功能障碍有关。方法。将 12 名以运动被动妄想为特征的精神分裂症患者的磁共振成像数据计算出的皮质体积与无被动妄想患者的皮质体积进行统计比较。结果。在被动组中，观察到顶叶和额叶联合皮层的皮层体积减少。结论。这些数据为顶叶参与精神分裂症被动妄想的病理生理学提供了直接证据。
Background. In patients with schizophrenia, passivity delusions are characterized by a difficulty in determining the agency of purposive actions. Neuropsychological and functional neuroimaging data suggest that passivity delusions are associated with dysfunction of the parietal lobe association cortex.Method. Cortical volume calculated from magnetic resonance imaging data in a group of 12 patients with schizophrenia characterized by motor passivity delusions was compared statistically with the cortical volume of I I patients without passivity delusions.Results. Reduced cortical volume was observed in parietal and frontal association cortices in the passivity group.Conclusions. These data provide direct evidence for the involvement of the parietal lobe in the pathophysiology of passivity delusions in schizophrenia.