DECREASED PRO-INFLAMMATORY CYTOKINES AND INCREASED ANTIOXIDANT ENZYME GENE-EXPRESSION BY OMEGA-3 LIPIDS IN MURINE LUPUS NEPHRITIS
DECREASED PRO-INFLAMMATORY CYTOKINES AND INCREASED ANTIOXIDANT ENZYME GENE-EXPRESSION BY OMEGA-3 LIPIDS IN MURINE LUPUS NEPHRITIS
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DOI：
10.1006/bbrc.1994.1534
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发表时间：
1994-04-29
影响因子：
3.1
通讯作者：
FERNANDES, G
中科院分区：
文献类型：
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作者：
CHANDRASEKAR, B;FERNANDES, G
与富含omega-6脂质的玉米油（CO）喂养小鼠相比，当随意喂养自身免疫性狼疮易感性NZ B/NZW F-1（B/W）雌性小鼠时，富含omega-3脂质的鲱鱼鱼油（FO）的饮食可延迟肾脏疾病的发作并减缓其进展，同时显著延长寿命。来自FO喂养小鼠的肾脏的北方印迹分析显示，与在CO喂养小鼠中容易检测到的水平相比，没有可检测到的IL-1 β IL-6和TNF α mRNA水平。与细胞因子相比，FO喂养的小鼠表现出较高的肾脏水平的抗氧化酶-过氧化氢酶，谷胱甘肽过氧化物酶（GSH-Px），超氧化物歧化酶（SOD）-mRNA相比，CO喂养的小鼠。结果表明，与CO相比，膳食补充FO抑制促炎细胞因子的产生，并可能通过增强细胞处理有害活性氧中间体的能力来改善免疫复合物介导的肾损伤。(C)1994年出版社出版。
Enrichment of diet with omega-3 lipid rich-menhaden fish oil (FO) when fed ad libitum to autoimmune lupus-prone NZB/NZW F-1 (B/W) female mice delayed the onset and slowed progression of renal disease while significantly extending life-span compared to omega-6 lipid rich-corn oil (CO)-fed mice. Northern blot analysis of kidneys from FO-fed mice revealed no detectable levels of IL-1 beta IL-6 and TNF alpha mRNA contrasted to levels that were easily detected in CO-fed mice. In contrast to the cytokines, FO-fed mice showed higher renal levels of the antioxidant enzymes-catalase, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD)-mRNAs compared to CO-fed mice. The results suggest that dietary supplementation with FO, as compared to CO, inhibits the production of pro-inflammatory cytokines and ameliorates immune-complex-mediated kidney injury possibly by enhancing the ability of cells to dispose of harmful reactive oxygen intermediates. (C) 1994 Academic Press, Inc.