Association between psoriasis and chronic obstructive pulmonary disease: a population-based study in Taiwan
Association between psoriasis and chronic obstructive pulmonary disease: a population-based study in Taiwan
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DOI：
10.1111/j.1468-3083.2011.04009.x
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发表时间：
2012-01-01
影响因子：
9.2
通讯作者：
Lin, H. -W.
中科院分区：
文献类型：
--
作者：
Chiang, Y. -Y.;Lin, H. -W.
背景银屑病被认为是一种全身性炎症性疾病，在最近的研究中，与广泛的全身性疾病有关。以前的研究报告银屑病和慢性阻塞性肺疾病（COPD）之间的正相关性，但是，没有研究已经进行了对中国人population.Methods的种族，我们进行了一项基于人群的研究，使用一个代表性的队列从国民健康保险数据库在台湾，2004年和2006年之间。比较银屑病患者和匹配的参考队列之间COPD的风险。结果在调整社会人口学特征和选定的慢性病后，银屑病患者COPD的危险比（HR）为2.35（95%可信区间（CI）：1.42-3.89），与对照组比较，随访18个月~ 4个月。男人（HR = 2.38，95% CI：1.36-4.18）和50岁以上银屑病患者（HR = 2.19，95% CI：1.27-3.77）更易患COPD。结论银屑病患者发生COPD的危险性更高，无COPD生存率明显低于对照组（P < 0.001）。医生应该意识到这种潜在的风险，以减少并发症和死亡率。
Background Psoriasis is regarded as a systemic inflammatory disease, having been linked in recent studies, to a wide range of systemic disorders. Previous studies have reported a positive correlation between psoriasis and chronic obstructive pulmonary disease (COPD); however, no studies have been conducted on an ethnic Chinese population.Methods We conducted a population-based study, using a representative cohort from the National Health Insurance database in Taiwan, between 2004 and 2006. The risk of COPD was compared between patients with psoriasis and a matched reference cohort. This study included 2096 psoriasis patients and 8384 randomly selected controls.Results After adjusting for sociodemographic characteristics and selected chronic diseases, the hazard ratio (HR) for COPD in psoriasis patients was 2.35 (95% confidence interval (CI): 1.42-3.89) compared with the control group in 18 months of follow-4 up. Men (HR = 2.38, 95% CI: 1.36-4.18) and patients with psoriasis over 50 years of age (HR = 2.19, 95% CI: 1.27-3.77) were more likely to contract COPD.Conclusions We concluded that psoriasis patients were at a greater risk of developing COPD with significantly lower COPD-free survival rates than the comparison cohort (P < 0.001). Physicians should be aware of this potential risk to reduce comorbidity and mortality.