Non-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy.
Non-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy.
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DOI：
10.1016/j.tranon.2021.101090
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发表时间：
2021-07
影响因子：
5
通讯作者：
Uysal-Onganer P
中科院分区：
文献类型：
--
作者：
Mortoglou M;Tabin ZK;Arisan ED;Kocher HM;Uysal-Onganer P
胰腺导管腺癌(PDAC)是最致命的恶性肿瘤之一，通常在晚期确诊。非编码RNA(NcRNAs)已被认为在PDAC的发病机制中起核心作用，可作为PDAC的生物标志物。在PDAC中，microRNAs(MiRs)既可以作为癌基因，也可以作为肿瘤抑制因子。长非编码RNA(LncRNAs)约占人类细胞总RNA分布的25%，它们的失控与PDAC的癌变密切相关。环状RNA(CircRNAs)作为miR分子海绵、RNA结合蛋白(RBP)海绵、蛋白质翻译器和基因转录调节因子，可作为PDAC诊断和治疗的潜在生物标志物和治疗靶点。胰腺导管腺癌(PDAC)是最具侵袭性的恶性肿瘤之一，其5年生存率不到8%，在过去的50年里一直没有变化。由于缺乏疾病特异性症状和可靠的生物标记物，早期检测尤其困难。综合治疗包括化疗、放疗(少用)和手术已成为PDAC患者的标准治疗方案。糖类抗原19-9(CA19-9)是最常见的诊断生物标志物，但对于无症状患者，其特异性还不够高。非编码RNA在人类恶性肿瘤中经常被解除调控，并被证明参与了与癌症相关的机制，如细胞生长、分化和细胞死亡。到目前为止，已经报道了几个参与PDAC的微型、长非编码和环状RNA。本文就非编码RNA在PDAC诊断和治疗中的作用和功能作一综述。
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, which is usually diagnosed at an advanced stage. Non-coding RNAs (ncRNAs) have been recognized to play a central role in PDAC pathogenesis and could be used as biomarkers for PDAC. microRNAs (miRs) can act either as oncogenes or tumour suppressors in PDAC. Long non-coding RNAs (lncRNAs) are around 25% of the total RNA distribution in the human cell and their deregulation is widely implicated in PDAC carcinogenesis. Circular RNAs (circRNAs) can be potential novel biomarkers and therapeutic targets for PDAC diagnosis and treatment via their function as miR molecular "sponges", RNA-binding protein (RBP) sponges, protein translators and gene transcription regulators. Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies with a 5-year survival rate less than 8%, which has remained unchanged over the last 50 years. Early detection is particularly difficult due to the lack of disease-specific symptoms and a reliable biomarker. Multimodality treatment including chemotherapy, radiotherapy (used sparingly) and surgery has become the standard of care for patients with PDAC. Carbohydrate antigen 19–9 (CA 19–9) is the most common diagnostic biomarker; however, it is not specific enough especially for asymptomatic patients. Non-coding RNAs are often deregulated in human malignancies and shown to be involved in cancer-related mechanisms such as cell growth, differentiation, and cell death. Several micro, long non-coding and circular RNAs have been reported to date which are involved in PDAC. Aim of this review is to discuss the roles and functions of non-coding RNAs in diagnosis and treatments of PDAC.
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DOI：
10.1038/nrc.2017.99
发表时间：
2018-01
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
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通讯作者：
Slack FJ
影响因子：
2.9
作者：
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通讯作者：
Schmittgen TD
影响因子：
37.3
作者：
Chen Z;Sangwan V;Banerjee S;Mackenzie T;Dudeja V;Li X;Wang H;Vickers SM;Saluja AK
通讯作者：
Saluja AK
Linc-RoR 通过 Hippo/YAP 通路促进胰腺癌细胞的增殖、迁移和侵袭
影响因子：
4
作者：
Chen, Wei;Wang, Huizhi;Xu, Min
通讯作者：
Xu, Min
DOI：
10.1158/1078-0432.ccr-14-0289
发表时间：
2014-11-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Chan A;Prassas I;Dimitromanolakis A;Brand RE;Serra S;Diamandis EP;Blasutig IM
通讯作者：
Blasutig IM