Sex differences in neural correlates of common psychopathological symptoms in early adolescence.
Sex differences in neural correlates of common psychopathological symptoms in early adolescence.
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DOI：
10.1017/s0033291720005140
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发表时间：
2022-10
影响因子：
6.9
通讯作者：
Schumann, Gunter
中科院分区：
文献类型：
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作者：
Biondo, Francesca;Thunell, Charlotte Nymberg;Xu, Bing;Chu, Congying;Jia, Tianye;Ing, Alex;Quinlan, Erin Burke;Tay, Nicole;Banaschewski, Tobias;Bokde, Arun L. W.;Buechel, Christian;Desrivieres, Sylvane;Flor, Herta;Frouin, Vincent;Garavan, Hugh;Gowland, Penny;Heinz, Andreas;Ittermann, Bernd;Martinot, Jean-Luc;Lemaitre, Herve;Nees, Frauke;Orfanos, Dimitri Papadopoulos;Poustka, Luise;Millenet, Sabina;Froehner, Juliane H.;Smolka, Michael N.;Walter, Henrik;Whelan, Robert;Barker, Edward D.;Schumann, Gunter
关键词：
精神病理学中与性别相关的差异是已知的现象，外化和内化症状通常分别在男孩和女孩中更常见。然而，这些精神病理性行为相互作用的神经相关性还没有得到充分研究，尤其是在青春期。参与者为14岁，是IMAGEN研究的一部分，这是一个基于社区的大样本(N=1526)。为了测试结构灰质体积(GMV)中性别与心理病理的交互作用，我们使用了基于稳健非参数方法的全脑、体素神经成像分析。精神病理症状数据来源于强项和困难问卷(SDQ)。我们在四个脑簇中发现了性多动/注意力不集中的交互作用：右侧顶盖-顶区(p<；0.01，Cohen‘s d=−0.24)，双侧扣带前部和中扣带回(p<；0.05，Cohen’s d=−0.18)，右侧小脑和梭形回(p<；0.05，Cohen‘s d=−0.20)，以及左额上中回(p<；0.05，Cohen’s d=−0.26)。多动/注意力不集中的症状越多，男孩所有四个脑簇的GMV就越低，女孩的顶顶脑-顶脑和小脑梭形脑簇的GMV就越高。我们的研究使用了一个大的、性别平衡的、以社区为基础的样本，支持了这样的观点，即多动/注意力不集中的外在症状可能与男性和女性青少年的不同神经结构有关。我们报告的大脑区域与无数重要的认知功能有关，特别是注意力、认知和运动控制以及时间安排，这些功能可能与理解多动和注意力不集中症状的行为表现有关。这项研究强调了在我们努力揭示青春期精神病理学潜在的机制时，考虑到性的重要性。
Sex-related differences in psychopathology are known phenomena, with externalizing and internalizing symptoms typically more common in boys and girls, respectively. However, the neural correlates of these sex-by-psychopathology interactions are underinvestigated, particularly in adolescence. Participants were 14 years of age and part of the IMAGEN study, a large (N = 1526) community-based sample. To test for sex-by-psychopathology interactions in structural grey matter volume (GMV), we used whole-brain, voxel-wise neuroimaging analyses based on robust non-parametric methods. Psychopathological symptom data were derived from the Strengths and Difficulties Questionnaire (SDQ). We found a sex-by-hyperactivity/inattention interaction in four brain clusters: right temporoparietal-opercular region (p < 0.01, Cohen's d = −0.24), bilateral anterior and mid-cingulum (p < 0.05, Cohen's d = −0.18), right cerebellum and fusiform (p < 0.05, Cohen's d = −0.20) and left frontal superior and middle gyri (p < 0.05, Cohen's d = −0.26). Higher symptoms of hyperactivity/inattention were associated with lower GMV in all four brain clusters in boys, and with higher GMV in the temporoparietal-opercular and cerebellar-fusiform clusters in girls. Using a large, sex-balanced and community-based sample, our study lends support to the idea that externalizing symptoms of hyperactivity/inattention may be associated with different neural structures in male and female adolescents. The brain regions we report have been associated with a myriad of important cognitive functions, in particular, attention, cognitive and motor control, and timing, that are potentially relevant to understand the behavioural manifestations of hyperactive and inattentive symptoms. This study highlights the importance of considering sex in our efforts to uncover mechanisms underlying psychopathology during adolescence.