Bioreducible micelles and hydrogels with tunable properties from multi-armed biodegradable copolymers
Bioreducible micelles and hydrogels with tunable properties from multi-armed biodegradable copolymers
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多臂可生物降解共聚物具有可调特性的生物可还原胶束和水凝胶
DOI：
10.1039/c1cc14663g
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Dong, Chang-Ming
中科院分区：
文献类型：
--
作者：
Sun, Lin;Liu, Wei;Dong, Chang-Ming
首次采用硫醇-炔点击化学法合成了以mPCL-b-PEO为生物可降解核的多臂生物可降解嵌段共聚物。它们在水溶液中自组装成可生物还原的胶束和水凝胶，表现出可调的尺寸，机械和药物释放性能。
Multi-armed biodegradable block copolymers with a bioreducible core mPCL-b-PEO were for the first time synthesized by thiol-yne click chemistry. They self-assembled into bioreducible micelles and hydrogels in aqueous solution, which demonstrated tunable size, mechanical and drug-release properties.