Trends in Lipids and Lipoproteins in US Adults, 1988-2010
Trends in Lipids and Lipoproteins in US Adults, 1988-2010
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DOI：
10.1001/jama.2012.13260
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发表时间：
2012-10-17
影响因子：
120.7
通讯作者：
Mussolino, Michael E.
中科院分区：
文献类型：
--
作者：
Carroll, Margaret D.;Kit, Brian K.;Mussolino, Michael E.
背景血清总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)参与动脉粥样硬化及其临床后果。在1988-1994年和1999-2002年期间，成年人的平均总胆固醇和平均低密度脂蛋白胆固醇下降。在此期间，接受降脂药物治疗的成年人比例有所增加。目的研究1988-2010年间成人血脂水平的变化趋势。设计、设置和参与者美国三项不同的横断面国民健康与营养检查调查，1988-1994(n=16 573)、1999-2002(n=9471)和2007-2010(n=11 766)。主要观察指标平均TC、LDL-C、HDLC、非HDLc和几何平均甘油三酯水平以及降脂药物的使用率。结果平均TC从206(95%CI，从1988-1994年的(205-207)mg/dL增加到2007-2010年的196(95%可信区间，195-198)mg/dL(P
Context Serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) contribute to atherosclerosis and its clinical consequences. Between the periods 1988-1994 and 1999-2002, mean TC and mean LDL-C declined in adults. During this time, there was an increase in the percentage of adults receiving lipid-lowering medications. Geometric mean triglyceride levels increased but mean high-density lipoprotein cholesterol (HDL-C) remained unchanged.Objective To examine trends in serum lipids in adults between 1988 and 2010.Design, Setting, and Participants Three distinct US cross-sectional National Health and Nutrition Examination Surveys, 1988-1994 (n=16 573), 1999-2002 (n=9471), and 2007-2010 (n=11 766).Main Outcome Measures Mean TC, LDL-C, HDL-C, non-HDL-C, and geometric mean triglyceride levels and the prevalence of lipid-lowering medication use.Results Mean TC declined from 206 (95% CI, 205-207) mg/dL in 1988-1994 to 196 (95% CI, 195-198) mg/dL in 2007-2010 (P