Genome-wide scan of resistin mRNA expression in omental adipose tissue of baboons.
Genome-wide scan of resistin mRNA expression in omental adipose tissue of baboons.
复制标题
狒狒网膜脂肪组织中抵抗素 mRNA 表达的全基因组扫描。
DOI：
10.1038/sj.ijo.0802699
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Comuzzie,AG
中科院分区：
文献类型：
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作者：
Tejero,ME;Cole,SA;Cai,G;Peebles,KW;Freeland-Graves,JH;Cox,LA;Mahaney,MC;Rogers,J;VandeBerg,JL;Blangero,J;Comuzzie,AG
METHODS:A 1 g omental adipose tissue biopsy was obtained from 404 adult baboons. Resistin mRNA expression was assayed by real-time, quantitative RT-PCR, and univariate and bivariate quantitative genetic analyses were performed, via the variance decomposition approach. A genome scan analysis was conducted using resistin mRNA abundance in omental adipose tissue as a quantitative phenotype.RESULTS:A significant heritability of h 2= 0.23 (P= 0.003) was found for resistin mRNA abundance in omental adipose tissue. A genome scan detected a quantitative trait locus for resistin expression with an LOD score of 3.8, in the region between markers D19S431 and D19S714, corresponding to human chromosome 19 p13. This chromosomal region contains genes related to insulin resistance phenotypes, such as resistin, insulin receptor, angiopoietin-like 4 protein and LDL receptor.CONCLUSIONS:Individual variation in resistin mRNA expression has a significant genetic component, and a gene or genes on chromosome 19p13 may regulate resistin mRNA levels in baboon omental adipose tissue.
