CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018
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DOI：
10.1093/neuonc/noab200
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发表时间：
2021-10-01
期刊：
影响因子：
15.9
通讯作者：
Barnholtz-Sloan, Jill S.
中科院分区：
文献类型：
--
作者：
Ostrom, Quinn T.;Cioffi, Gino;Barnholtz-Sloan, Jill S.
美国中央脑肿瘤登记处（CBTRUS）与疾病控制和预防中心（CDC）和国家癌症研究所（NCI）合作，是美国（US）最大的基于人群的癌症登记处，专门关注原发性脑和其他中枢神经系统（CNS）肿瘤，代表整个美国人口。本报告包含了最新的基于人群的原发性脑肿瘤数据，在完整性和准确性方面取代了所有以前的报告，是第一份提供选定脑和CNS肿瘤组织学分子标志物分布的CBTRUS报告。所有恶性和非恶性脑肿瘤和其他CNS肿瘤的平均年年龄调整发病率（AAAIR）为24.25（恶性AAAIR=706，非恶性AAAIR=17.18）。女性的总体比率高于男性（26.95比21.35），非西班牙裔高于西班牙裔（24.68比22.12）。最常见的恶性脑和其他CNS肿瘤是胶质母细胞瘤（占所有肿瘤的14.3%和恶性肿瘤的49.1%），最常见的非恶性肿瘤是脑膜瘤（占所有肿瘤的39.0%和非恶性肿瘤的54.5%）。胶质母细胞瘤多见于男性，脑膜瘤多见于女性。在儿童和青少年（0-19岁）中，所有原发性脑肿瘤和其他CNS肿瘤的发病率为6.21。预计2021年美国人群中将诊断出88，190例恶性和非恶性脑肿瘤和其他CNS肿瘤新发病例（25，690例恶性和62，500例非恶性）。2014年至2018年期间，有83，029人死于恶性脑肿瘤和其他CNS肿瘤。这意味着年平均死亡率为每100 000人中有4.43人死亡，平均每年有16 606人死亡。诊断为恶性脑肿瘤和其他CNS肿瘤后的5年相对生存率为35.6%，非恶性脑肿瘤和其他CNS肿瘤的5年相对生存率为91.8%。
The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control and Prevention (CDC) and National Cancer Institute (NCI), is the largest population-based cancer registry focused exclusively on primary brain and other central nervous system (CNS) tumors in the United States (US) and represents the entire US population. This report contains the most up-to-date population-based data on primary brain tumors available and supersedes all previous reports in terms of completeness and accuracy and is the first CBTRUS Report to provide the distribution of molecular markers for selected brain and CNS tumor histologies. All rates are age-adjusted using the 2000 US standard population and presented per 100,000 population.The average annual age-adjusted incidence rate (AAAIR) of all malignant and non-malignant brain and other CNS tumors was 24.25 (Malignant AAAIR=706, Non-malignant AAAIR=17.18). This overall rate was higher in females compared to males (26.95 versus 21.35) and non-Hispanics compared to Hispanics (24.68 versus 22.12). The most commonly occurring malignant brain and other CNS tumor was glioblastoma (14.3% of all tumors and 49.1% of malignant tumors), and the most common non-malignant tumor was meningioma (39.0% of all tumors and 54.5% of nonmalignant tumors). Glioblastoma was more common in males, and meningioma was more common in females. In children and adolescents (age 0-19 years), the incidence rate of all primary brain and other CNS tumors was 6.21. An estimated 88,190 new cases of malignant and non-malignant brain and other CNS tumors are expected to be diagnosed in the US population in 2021 (25,690 malignant and 62,500 non-malignant). There were 83,029 deaths attributed to malignant brain and other CNS tumors between 2014 and 2018. This represents an average annual mortality rate of 4.43 per 100,000 and an average of 16,606 deaths per year. The five-year relative survival rate following diagnosis of a malignant brain and other CNS tumor was 35.6%, for a non-malignant brain and other CNS tumors the five-year relative survival rate was 91.8%.