Pain processing within the primary somatosensory cortex in humans
Pain processing within the primary somatosensory cortex in humans
复制标题
DOI：
10.1111/j.1460-9568.2003.02995.x
复制
发表时间：
2003-11-01
影响因子：
3.4
通讯作者：
Kakigi, R
中科院分区：
文献类型：
--
作者：
Inui, K;Wang, XH;Kakigi, R
为了研究初级躯体感觉皮层（SI）对伤害性刺激的处理，我们记录了左手背部伤害性表皮电刺激（ES）和无害性经皮电刺激（TS）后的脑磁图。TS在SI内依次激活两个来源：一个在中央沟的后堤，另一个在中央后回的冠部，分别对应于Brodmann的3b区和1区。来自区域3b的活动包括20-和30-ms响应。从1区的活动包括三个组件峰值在26，36和49毫秒。ES激活SI内的一个源，其位置和方向是类似的TS激活区1源。来自该源的活动由三个分量组成，峰值在88、98和109 ms，比相应的TS响应晚60 ms。ES和TS随后激活了一个类似的区域在上银行的侧裂，对应于次级体感皮层（SII）。ES后SII活动的起始潜伏期（109 ms）比首次SI反应的起始潜伏期（80 ms）晚29 ms。TS后SII区活动的起始潜伏期（52 ms）比SI区1的起始潜伏期（17 ms）晚35 ms。因此，我们的研究结果表明，有害和无害的刺激的处理是相似的，除了有没有可检测的激活区域3b内的伤害性刺激后，SI和SII内的源位置和激活时间。
To investigate the processing of noxious stimuli within the primary somatosensory cortex (SI), we recorded magnetoencephalography following noxious epidermal electrical stimulation (ES) and innocuous transcutaneous electrical stimulation (TS) applied to the dorsum of the left hand. TS activated two sources sequentially within SI: one in the posterior bank of the central sulcus and another in the crown of the postcentral gyrus, corresponding to Brodmann's areas 3b and 1, respectively. Activities from area 3b consisted of 20- and 30-ms responses. Activities from area 1 consisted of three components peaking at 26, 36 and 49 ms. ES activated one source within SI whose location and orientation were similar to those of the TS-activated area 1 source. Activities from this source consisted of three components peaking at 88, 98 and 109 ms, later by 60 ms than the corresponding TS responses. ES and TS subsequently activated a similar region in the upper bank of the sylvian fissure, corresponding to the secondary somatosensory cortex (SII). The onset latency of the SII activity following ES (109 ms) was later by 29 ms than that of the first SI response (80 ms). Likewise, the onset latency of SII activity following TS (52 ms) was later by 35 ms than that of area 1 of SI (17 ms). Therefore, our results showed that the processing of noxious and innocuous stimuli is similar with respect to the source locations and activation timings within SI and SII except that there were no detectable activations within area 3b following noxious stimulation.