Temperature Driven Self-Assembly of a Zwitterionic Block Copolymer That Exhibits Triple Thermoresponsivity and pH Sensitivity
Temperature Driven Self-Assembly of a Zwitterionic Block Copolymer That Exhibits Triple Thermoresponsivity and pH Sensitivity
复制标题
DOI：
10.1021/acs.macromol.5b00769
复制
发表时间：
2015-06
期刊：
影响因子：
5.5
通讯作者：
Zulma A. Jiménez;R. Yoshida
中科院分区：
文献类型：
--
作者：
Zulma A. Jiménez;R. Yoshida
我们报道了一种由N-异丙基丙烯酰胺和N，N-二甲基-N-（3-（甲基丙烯酰胺基）丙基）铵基丙磺酸酯单体组成的两性离子嵌段共聚物，该共聚物根据溶液温度自组装成不同的结构。随着温度从20 °C增加到70 °C，聚合物的溶解度从不溶性到可溶性到不溶性到可溶性的方向转换。在此过程中，聚合物的自组装从聚合物囊泡到胶束。这些非凡的转变是可能的，因为聚合物嵌段的疏水-疏水比和连接到聚（N-异丙基丙烯酰胺）链的末端的羧基端基的存在。此外，由于羰基的质子化-去质子化和铵部分的电荷中和，这些转变之一可以通过溶液的pH来控制。目前的工作打开了设计具有温度驱动的自组装性能的聚合物的可能性，可用于双金属。
We report a zwitterionic block copolymer composed of N-isopropylacrylamide and N,N-dimethyl-N-(3-(methacrylamido)propyl)ammoniopropanesulfonate monomers which self-assembles into different structures depending on the solution temperature. As the temperature is increased from 20 to 70 °C, the solubility of the polymer switches direction from insoluble to soluble to insoluble to soluble. During this process, the polymer self-assembly changes from polymersomes to micelles. These extraordinary transitions are possible because of the hydrophilic–hydrophobic ratio of the polymer blocks and the presence of a carboxyl end group attached to the end of the poly(N-isopropylacrylamide) chain. Additionally, one of these transitions can be controlled by the pH of the solution thanks to the protonation–deprotonation of the carbonyl and the charge neutralization of the ammonium moieties. The present work opens the possibility of designing polymers with temperature driven self-assembly properties that could be used for bi...