Atorvastatin enhances bone density in ovariectomized rats given 17β-estradiol or human parathyroid hormone(1–34)
Atorvastatin enhances bone density in ovariectomized rats given 17β-estradiol or human parathyroid hormone(1–34)
复制标题
阿托伐他汀可增强给予 17β-雌二醇或人甲状旁腺激素的卵巢切除大鼠的骨密度 (1–34)
DOI：
10.1385/endo:24:2:121
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发表时间：
2004
期刊：
影响因子：
3.7
通讯作者：
N. Horiuchi
中科院分区：
文献类型：
--
作者：
T. Kawane;Shinichi Terashima;Izuru Kurahashi;T. Yanagawa;H. Yoshida;N. Horiuchi
我们研究了阿托伐他汀对卵巢切除 (OVX) 大鼠骨矿物质密度 (BMD) 的体内影响。八周龄雌性大鼠接受假手术或卵巢切除术，并在手术后 6 周开始使用媒介物、阿托伐他汀、17β-雌二醇 (E2) 和人甲状旁腺激素 (1–34) [hPTH(1–34)] 进行治疗。 E2（10 µg/kg）治疗12周显着增加腰椎BMD（L2-L4），而阿托伐他汀不影响腰椎BMD。与单独使用 E2 或阿托伐他汀相比，阿托伐他汀 (2 mg/kg) 和 E2 的组合显着增强了腰椎 (L2–L4) 和股骨干骺端区域（距离最近点的 2/10–4/10 节段）的 BMD。低剂量 1 µg/kg hPTH (1-34) 不会改变腰椎或股骨 BMD，而高剂量 17.5 µg/kg 肽则显着增加 BMD。同时注射阿托伐他汀 (2 mg/kg) 和 hPTH(1–34) (1 µg/kg) 8 周可显着增强 OVX 大鼠腰椎和股骨干骺端区域的 BMD。这些发现表明，长期服用阿托伐他汀似乎会适度增强接受次最大剂量 E2 和 hPTH 治疗的 OVX 大鼠的腰椎和股骨干骺端的 BMD (1-34)。
We investigated the in vivo effect of atorvastatin on bone mineral density (BMD) in ovariectomized (OVX) rats. Eight-week-old female rats underwent either a sham operation or ovariectomy, and treatments with vehicle, atorvastatin, 17β-estradiol (E2) and human parathyroid hormone(1–34) [hPTH(1–34)] were initiated 6 wk after the surgery. E2 (10 µg/kg) treatment for 12 wk significantly increased lumbar BMD (L2–L4), whereas atorvastatin did not affect lumbar BMD. The combination of atorvastatin (2 mg/kg) and E2 significantly enhanced the BMD of lumbar vertebrae (L2–L4) and femoral metaphyseal area (2/10–4/10 segments from the most proximal point) compared to that of either E2 or atorvastatin alone. A low dose 1 µg/kg of hPTH (1–34) did not alter lumbar or femoral BMD, whereas a high dose 17.5 µg/kg of the peptide significantly increased BMD. Concomitant injections of atorvastatin (2 mg/kg) with hPTH(1–34) (1 µg/kg) for 8 wk significantly enhanced the BMD of lumbar vertebrae and the metaphyseal area of the femur in OVX rats. These findings demonstrate that chronic administration of atorvastatin appears to modestly enhance the BMD of the lumbar vertebrae and femoral metaphysis of OVX rats treated with submaximal doses of E2 and hPTH(1–34).
影响因子：
82.9
作者：
Kureishi, Y;Luo, ZY;Walsh, K
通讯作者：
Walsh, K
影响因子：
37.8
作者：
Maron, DJ;Fazio, S;Linton, MF
通讯作者：
Linton, MF