Increased levels of serum soluble L-selectin in unmedicated patients with schizophrenia
Increased levels of serum soluble L-selectin in unmedicated patients with schizophrenia
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DOI：
10.1016/j.schres.2006.08.026
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发表时间：
2007-01-01
影响因子：
4.5
通讯作者：
Mori, Norio
中科院分区：
文献类型：
--
作者：
Iwata, Yasuhide;Suzuki, Katsuaki;Mori, Norio
目的：许多研究表明精神分裂症与免疫功能改变有关。粘附分子的选择素家族在免疫/炎症反应中起着重要作用。为了进一步研究精神分裂症的免疫病理生理过程，我们测定了精神分裂症患者血清中选择素的水平。特异性，我们还调查了选择素水平在患者major depression.Method：我们研究了23未服药的精神分裂症患者，17未服药的抑郁症患者，和36名健康人。结果：精神分裂症患者血清sL-选择素水平显著高于正常对照组（p=0.005）和抑郁症患者（p =0.02）;血清SE-选择素和sP-选择素水平无显著性差异。结论：精神分裂症患者血清sL-选择素水平升高可能代表免疫系统功能紊乱，可能参与了精神分裂症的发病机制。(c)2006 Elsevier B. V.保留所有权利。
Objective: Numerous studies have linked schizophrenia with altered immune function. The selectin family of adhesion molecules plays a prominent role in immune/inflammatory responses. To further study the immunological processes in the pathophysiology of schizophrenia, we determined the serum levels of selectins in patients with schizophrenia. For specificity, we also investigated selectin levels in patients with major depression.Method: We studied 23 unmedicated patients with schizophrenia, 17 unmedicated patients with major depression, and 36 healthy subjects. The serum levels of three types of soluble-form selectin (sE-, sL- and sP-selectin) were determined by enzyme-linked immunosorbent assay (ELISA).Results: Serum sL-selectin levels were significantly higher in patients with schizophrenia than in either control subjects (p=0.005) or patients with major depression (p=0.02). No significant difference was found with regard to the level of either serum SE-selectin or sP-selectin.Conclusion: Elevated sL-selectin levels in patients with schizophrenia may represent immune system dysfunction and may be involved in the pathogenesis of the illness. (c) 2006 Elsevier B.V. All rights reserved.