Pharmacogenomics of preterm birth prevention and treatment.
Pharmacogenomics of preterm birth prevention and treatment.
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DOI：
10.1111/1471-0528.13744
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Manuck TA
中科院分区：
文献类型：
--
作者：
Manuck TA
药物基因组学和个性化医疗结合遗传因素，历史数据和环境暴露来预测个体对药物的反应。药理学和药物基因组学的研究是具有挑战性的产科，知识落后于其他学科的医学。然而，一些初步的数据表明，一些个体间的变化，在为预防（黄体酮）和治疗（硝苯地平，特布他林，其他）早产的药物反应可能是由于药物基因组学的影响。迫切需要一种综合方法，整合临床数据、环境因素（包括伴随用药）和基因型，以优化早产的预防和治疗策略。
Pharmacogenomics and personalized medicine incorporate genetic factors, historical data, and environmental exposures to predict individual variation in response to medications. The study of pharmacology and pharmacogenomics is challenging in obstetrics, and knowledge lags behind other disciplines of medicine. However, some preliminary data suggest that some of the inter-individual variation seen in response to medications given for the prevention (progesterone) and treatment (nifedipine, terbutaline, others) of preterm labor may be due to pharmacogenomic effects. A comprehensive approach, integrating clinical data, environmental factors including concomitant medications, and genotype to optimize prevention and treatment strategies for preterm birth, is urgently needed.