Racial/Ethnic Disparities in Young Adulthood and Midlife Cardiovascular Risk Factors and Late-life Cognitive Domains: The Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) Study.
Racial/Ethnic Disparities in Young Adulthood and Midlife Cardiovascular Risk Factors and Late-life Cognitive Domains: The Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) Study.
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DOI：
10.1097/wad.0000000000000436
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发表时间：
2021-04-01
影响因子：
2.1
通讯作者：
Whitmer RA
中科院分区：
文献类型：
--
作者：
Peterson RL;George KM;Gilsanz P;Ackley S;Mayeda ER;Glymour MM;Mungas DM;DeCarli C;Whitmer RA
Midlife cardiovascular risk factors (CVRF) increase dementia risk. Less is known about whether CVRF identified before midlife impact late-life cognition in diverse populations. Linear regression models examined hypertension, hyperlipidemia, and overweight/obesity at ages 30–59 with late-life executive function, semantic memory, verbal episodic memory and global cognition in a cohort of Asians, Blacks, Latinos, and Whites (n=1,127; mean age=75.8, range 65–98). Models adjusted for age at CVRF, age at cognitive assessment, gender, race/ethnicity, participant education and parental education. Thirty-four percent had 1 CVRF at ages 30–59; 19% had 2+. Blacks (26%) and Latinos (23%) were more likely to have 2+ CVRF than Asians (14%) or Whites (13%). Having 2+ CVRF was associated with lower global cognition (β=−0.33; 95% CI=−0.45, −0.21), executive function (β=−0.26; 95% CI=−0.39, −0.13), verbal episodic memory (β=−0.34; 95% CI=−0.48, −0.20), and semantic memory (β=−0.20; 95% CI=−0.33, −0.07). Interaction by age (p=0.06) indicated overweight/obesity was negatively associated with executive function at ages 30–39 but not at ages 40–59. Race/ethnic-specific effects showed disparities in CVRF prevalence impacts population disparities in late-life cognition. Being overweight/obese in early adulthood and having 2+ CVRF in early adulthood/midlife are modifiable targets to redress racial/ethnic disparities in cognitive impairment and dementia.
