ACETATE METABOLISM IN NERVOUS SYSTEM . N-ACETYL-L-ASPARTIC ACID AND BIOSYNTHESIS OF BRAIN LIPIDS
ACETATE METABOLISM IN NERVOUS SYSTEM . N-ACETYL-L-ASPARTIC ACID AND BIOSYNTHESIS OF BRAIN LIPIDS
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DOI：
10.1111/j.1471-4159.1966.tb10292.x
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发表时间：
1966-01-01
影响因子：
4.7
通讯作者：
YATSU, FM
中科院分区：
文献类型：
--
作者：
DADAMO, AF;YATSU, FM
N-乙酰基-L-天冬氨酸不像以前认为的那样具有代谢惰性，但会为体内脑脂质合成提供乙酰基。双标实验表明，所利用的是乙酰化氨基酸的L形式；与双标记乙酸盐的比较表明，乙酰基团进入相似的池中。
N-Acetyl-L-aspartic acid is not metabolically inert as previously thought but will provide acetyl groups for brain lipid synthesis in vivo. Double label experiments show that it is the L form of the acetylated amino acid which is utilized; a comparison with double labelled acetate shows that the acetyl groups enter similar pools.