Changes in the period of no respiratory sensation and total breath-holding time in successive breath-holding trials
Changes in the period of no respiratory sensation and total breath-holding time in successive breath-holding trials
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DOI：
10.1042/cs0910755
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发表时间：
1996-12-01
期刊：
影响因子：
6
通讯作者：
Ishikawa, T
中科院分区：
文献类型：
--
作者：
Nishino, T;Sugimori, K;Ishikawa, T
1.在呼气末水平屏气后，立即存在一段特定的无呼吸感觉的时间，该时间段以不愉快感觉的开始而终止，随后是屏气期间的渐进性不适。该时间段定义为从自主屏气开始到发生不愉快感觉的时间点的时间，被指定为"无呼吸感觉的时间段"，虽然已经表明，最大的屏气性能提高了连续的试验，目前还不清楚是否这种训练效果施加在屏气期间没有呼吸感觉的时间类似的影响，2。由于训练效果似乎与屏气的压力有关，我们假设屏气过程中无呼吸感觉的初始阶段可能受训练效果的影响较小。本文对13名正常人进行了多次屏气，同时用视觉模拟评分法连续评定呼吸不适。此外，我们还测量了每个人的高碳酸反应曲线，并得出了高碳酸反应曲线的斜率与屏气时间的关系。我们的结果表明，训练对无呼吸感觉期的影响很小，并且屏气期间无感觉期与高碳酸通气反应曲线的斜率呈负相关，5。对8例慢性阻塞性肺疾病患者进行了无呼吸感觉期测定，结果慢性阻塞性肺疾病患者无呼吸感觉期明显低于正常人。这些发现表明，测量无呼吸感觉的时间可以是一个有用的临床试验的研究呼吸困难的成因。
1. Immediately after breath-holding at end-expiratory level, there is a certain period of no particular respiratory sensation which is terminated by the onset of an unpleasant sensation and followed by progressive discomfort during breath-holding, This period, defined as the time from the start of voluntary breath-holding to the point where the onset of an unpleasant sensation occurs, is designated 'the period of no respiratory sensation', Although it has been shown that the maximum breath-holding performance is improved with successive trials, it is not clear whether this training effect exerts a similar influence on the period of no respiratory sensation during breath-holding,2. Since the training effect seems to be associated with the stresses of breath-holding, we hypothesized that the initial period of no respiratory sensation during breath-holding might be less influenced by the training effect,3. We studied 13 normal subjects who performed repeated breath holds while continuously rating their respiratory discomfort using a visual analogue scale, In addition, we measured the hypercapnic ventilatory response of each individual and obtained the relationship between the slope of the hypercapnic response curve and breath-holding periods,4. Our results showed that there was little training effect on the period of no respiratory sensation and that the period of no sensation during breath-holding is inversely related to the slope of the hypercapnic ventilatory response curve,5. The period of no respiratory sensation was also measured in eight patients with chronic obstructive pulmonary disease, The values of the period of no respiratory sensation in patients,vith chronic obstructive pulmonary disease were apparently lower than those obtained in normal subjects,6. These findings suggest that measurement of the period of no respiratory sensation can be a useful clinical test for the study of genesis of dyspnoea.