Proton magnetic resonance spectroscopy of the primary motor cortex in patients with motor neuron disease -: Subgroup analysis and follow-up measurements
Proton magnetic resonance spectroscopy of the primary motor cortex in patients with motor neuron disease -: Subgroup analysis and follow-up measurements
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DOI：
10.1001/archneur.55.7.931
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发表时间：
1998-07-01
影响因子：
--
通讯作者：
Jerusalem, F
中科院分区：
文献类型：
--
作者：
Block, W;Karitzky, J;Jerusalem, F
目的：为了确定运动皮质变性与肌萎缩侧索硬化症（ALS）患者使用质子磁共振波谱，并证明质子磁共振波谱适合监测病程与后续examinations.Materials和方法：我们研究了33例ALS患者的条件被诊断为Fl埃斯科里亚尔世界神经病学联合会的标准。9例ALS患者随访长达2年。对照组包括20名健康志愿者和4名多灶性运动神经病患者。质子磁共振波谱测定脑代谢物N-乙酰天冬氨酸（NAA）、胆碱、肌醇化合物、谷氨酸/谷氨酰胺和磷酸肌酸的水平。
Objectives: To determine the motor cortex degeneration in patients with amyotrophic lateral sclerosis (ALS) using proton magnetic resonance spectroscopy, and to prove that proton magnetic resonance spectroscopy is suited to monitor the course of disease with follow-up examinations.Materials and Methods: We studied 33 patients with ALS whose conditions were diagnosed according to the Fl Escorial World Federation of Neurology criteria. Nine patients with ALS were followed up for up to 2 years. The control group included 20 healthy volunteers and 4 patients with multifocal motor neuropathy. Proton magnetic resonance spectroscopy determined levels of the brain metabolites N-acetylaspartate (NAA), choline, inositol-containing compounds, glutamate/glutamine, and phosphocreatine.Results: Patients with ALS showed a significant reduction in the NAA), choline (P