The Classification of Protein Domains
The Classification of Protein Domains
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DOI：
10.1007/978-1-4939-6622-6_7
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发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Orengo, Christine A.
中科院分区：
文献类型：
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作者：
Dawson, Natalie;Sillitoe, Ian;Orengo, Christine A.
我们现在目睹的蛋白质序列和结构数据的显着扩展带来了迫切需要为蛋白质世界带来秩序的需求。这样的顺序使我们能够深入了解蛋白质的演变，其功能以及功能曲目在生命的三个王国中可以变化的程度。这导致创造了广泛的蛋白质家族分类，旨在根据其进化关系进行分组。在本章中，我们讨论了经常用于蛋白质分类的方法和方法，并特别强调蛋白质结构域的分类。考虑了域序列和域结构数据库的构建，我们展示了域家族注释来分配结构和功能信息的使用如何增强我们对基因组的理解。
The significant expansion in protein sequence and structure data that we are now witnessing brings with it a pressing need to bring order to the protein world. Such order enables us to gain insights into the evolution of proteins, their function and the extent to which the functional repertoire can vary across the three kingdoms of life. This has lead to the creation of a wide range of protein family classifications that aim to group proteins based upon their evolutionary relationships.In this chapter we discuss the approaches and methods that are frequently used in the classification of proteins, with a specific emphasis on the classification of protein domains. The construction of both domain sequence and domain structure databases is considered and we show how the use of domain family annotations to assign structural and functional information is enhancing our understanding of genomes.