Social, reward, and attention brain networks are involved when online bids for joint attention are met with congruent versus incongruent responses
Social, reward, and attention brain networks are involved when online bids for joint attention are met with congruent versus incongruent responses
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DOI：
10.1080/17470919.2013.832374
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发表时间：
2013-11-01
影响因子：
2
通讯作者：
Vander Wyk, Brent C.
中科院分区：
文献类型：
--
作者：
Gordon, Ilanit;Eilbott, Jeffrey A.;Vander Wyk, Brent C.
共同注意（JA）是人类适应性社会功能的基石。很少有功能性磁共振成像（fMRI）研究在互动范式中考察了JA出价的神经激活，遇到了一致或不一致的社会反应。我们开发了一种高度自然的fMRI范式，利用眼动追踪来创建参与者发起的JA的实时、偶然的社会反应。在对JA投标的一致反应中，我们观察到右侧杏仁核、右侧梭状回、前扣带皮层、纹状体、腹侧被盖区和后顶叶皮层的激活增加。对JA出价的不一致反应引起了位于右侧颞顶交界处（TPJ）和双侧小脑的活动增加。在一致或不一致的试验中，没有观察到眼睛注视模式的差异。我们的研究结果强调了在社会神经科学中利用交互式功能磁共振成像范式的重要性，以及一致性在招募综合社会、奖励和注意回路以处理JA方面的影响。
Joint attention (JA) is a cornerstone of adaptive human social functioning. Little functional magnetic resonance imaging (fMRI) research has examined, in interactive paradigms, neural activation underlying bids for JA, met with a congruent or an incongruent social response. We developed a highly naturalistic fMRI paradigm utilizing eye-tracking to create real-time, contingent social responses to participant-initiated JA. During congruent responses to JA bids, we observed increased activation in the right amygdala, the right fusiform gyrus, anterior and dorsal anterior cingulate cortices, striatum, ventral tegmental area, and posterior parietal cortices. Incongruent responses to JA bids elicited increased activity localized to the right temporoparietal junction (TPJ) and bilateral cerebellum. No differences in eye-gaze patterns were observed during congruent or incongruent trials. Our results highlight the importance of utilizing interactive fMRI paradigms in social neuroscience and the impact of congruency in recruiting integrated social, reward, and attention circuits for processing JA.