Roles of VEGF-Flt-1 signaling in malignant behaviors of oral squamous cell carcinoma
Roles of VEGF-Flt-1 signaling in malignant behaviors of oral squamous cell carcinoma
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DOI：
10.1371/journal.pone.0187092
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发表时间：
2017-11-17
期刊：
影响因子：
3.7
通讯作者：
Takata, Takashi
中科院分区：
文献类型：
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作者：
Subarnbhesaj, Ajiravudh;Miyauchi, Mutsumi;Takata, Takashi
背景血管内皮生长因子（Vascular endothelial growth factor，VEGF）是一种高度特异性的血管内皮细胞信号蛋白，在肿瘤的生长和血管生成中起关键作用，并可能促进细胞迁移和破骨细胞前体的活化，目的：阐明VEGF-Flt-1信号在口腔鳞状细胞癌（OSCC）细胞骨侵袭中的作用。42例（77.8%）牙龈鳞状细胞癌VEGF强表达，Flt-1+破骨细胞数量显著增加（p
BackgroundVascular endothelial growth factor (VEGF) is a highly specific signaling protein for vascular endothelial cells that plays a critical role in tumor growth and invasion through angiogenesis, and may contribute to cell migration and activation of pre-osteoclasts, osteoclasts and some tumor cells.ObjectivesWe aimed to clarify the detailed roles of VEGF-Flt-1 signaling in bone invasion of oral squamous cell carcinoma (OSCC) cells.ResultsForty-two (42) of 54 cases with gingival SCC (77.8%) strongly expressed VEGF, and had a significantly increased number of Flt-1+ osteoclasts (p