Prevalence of glucose-6-phosphate dehydrogenase deficiency in US Army personnel
Prevalence of glucose-6-phosphate dehydrogenase deficiency in US Army personnel
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DOI：
10.7205/milmed.171.9.905
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发表时间：
2006-09-01
影响因子：
1.2
通讯作者：
Hospenthal, Duane R.
中科院分区：
文献类型：
--
作者：
Murray, Clinton K.;Chinevere, Troy D.;Hospenthal, Duane R.
美国陆军最近要求士兵在部署到疟疾流行地区之前接受葡萄糖-6-磷酸脱氢酶（G6 PD）测试。我们通过2004年10月1日至2005年1月17日获得的测试结果，回顾性地描述了美国军人中G6 PD缺乏症的存在和程度，包括性别、自我报告的种族和世界卫生组织的缺乏症分类。63，302例受试者（54，874例男性和8，428例女性）的数据可用; 2.5%的男性和1.6%的女性缺乏酶，大多数仅中度缺乏酶。非洲裔美国男性（12.2%）和女性（4.1%），沿着亚洲男性（4.3%），G6 PD缺乏率最高。大多数男性被发现有HI类变异，而大多数女性是IV类变异。最严重的缺陷是亚洲男性（II类）。这些结果表明，G6 PD缺乏症的普遍筛查在临床上是必要的，对于那些自我报告种族为非洲裔美国人，亚洲人或西班牙裔的男性服务人员尤其重要。
The U.S. Army recently mandated that soldiers undergo glucose-6-phosphate dehydrogenase (G6PD) testing before deployment to malarious regions. We retrospectively characterize the presence and degree of G6PD deficiency in U.S. military personnel by sex, self-reported ethnicity, and World Health Organization deficiency classification through test results obtained October 1, 2004 through January 17, 2005. Data were available for 63,302 (54,874 males and 8,428 females) subjects; 2.5% of males and 1.6% of females were deficient, with most having only moderate enzyme deficiency. African American males (12.2%) and females (4.1%), along with Asian males (4.3%), had the highest rates of G6PD deficiency. Most males were found to have class HI variants while most females were class IV variants. The most severely deficient were Asian males (class II). These results suggest that universal screening for G6PD deficiency is clinically warranted, and particularly essential for those male service members who self-report ethnicity as African American, Asian, or Hispanic.