Ultradian variations of chromogranin A in humans.
Ultradian variations of chromogranin A in humans.
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人类嗜铬粒蛋白 A 的超电变化。
DOI：
10.1152/ajpregu.1991.261.4.r939
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
O'Connor,DT
中科院分区：
文献类型：
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作者：
Takiyyuddin,MA;Neumann,HP;Cervenka,JH;Kennedy,B;Dinh,TQ;Ziegler,MG;Baron,AD;O'Connor,DT
嗜铬粒蛋白A（Chromogranin A，CgA）是一种酸性可溶性蛋白质，可从神经内分泌囊泡中分泌。在这里，我们研究了CGA和儿茶酚胺浓度在人类的自发变化。在正常受试者中，基础CgA没有表现出每日，每周或昼夜变化。血浆CgA有显着的ultradian变化在血压正常和高血压，并在双侧肾上腺切除术的主题。性别，而不是年龄或血压，影响CgA的变化，男性有较少的（P <0.05）峰每8小时。血浆儿茶酚胺有显着的ultradian变化在控制和双侧肾上腺切除受试者。在个人，无论是基础还是峰值血浆CGA与儿茶酚胺，也没有血浆CGA和儿茶酚胺峰值之间的一致性。生长抑素是一种广泛的非交感肾上腺神经内分泌抑制剂，减少了血浆CgA峰的频率和幅度。因此，基础CgA的自发性变化与交感肾上腺儿茶酚胺分泌的改变没有直接联系。此外，在交感肾上腺系统以外的其他部位的神经内分泌有助于CgA浓度的自发变化。
Chromogranin A (CgA) is an acidic soluble protein exocytotically released from virtually all neuroendocrine secretory vesicles. Here we examined spontaneous variations in CgA and catecholamine concentrations in humans. In normal subjects, basal CgA showed no day-to-day, week-to-week, or diurnal variability. Plasma CgA had significant ultradian variation in normotensives and hypertensives, and in bilaterally adrenalectomized subjects. Gender, but not age or blood pressure, influenced CgA variations, males having fewer (P less than 0.05) peaks per 8 h. Plasma catecholamines had significant ultradian variations in both controls and bilaterally adrenalectomized subjects. Within individuals, neither basal nor peak plasma CgA correlated with catecholamines, nor was there concordance between plasma CgA and catecholamine peaks. Somatostatin, a widespread inhibitor of nonsympathoadrenal neuroendocrine secretion, diminished both the frequency and amplitude of plasma CgA peaks. Thus spontaneous variations in basal CgA are not directly linked to alterations in sympathoadrenal catecholamine secretion. Furthermore, neuroendocrine secretion at sites other than the sympathoadrenal system contributes to spontaneous variations in CgA concentration.