Influence of fMRI smoothing procedures on replicability of fine scale motor localization
Influence of fMRI smoothing procedures on replicability of fine scale motor localization
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DOI：
10.1016/j.neuroimage.2004.08.042
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发表时间：
2005-01-15
期刊：
影响因子：
5.7
通讯作者：
Beisteiner, R
中科院分区：
文献类型：
--
作者：
Geissler, A;Lanzenberger, R;Beisteiner, R
最近的出版物分析了空间平滑油fMRI脑激活结果的影响，表明平滑可以人为地将来自相邻但功能和解剖学上不同的脑区域的激活联合收割机组合，并且来自大引流血管的激活可以平滑到相邻的神经元组织中。为了研究功能定位是否可以人为地移动的平滑过程中，我们进行了可重复性测量。在不同的条件下（孤立的手运动和同时的手和下巴运动）实现的运动手激活的本地化中心进行了比较与平滑效果。用非平滑和标准4 x 4 x 6 mm平滑相关数据分析技术定位具有最高概率代表真阳性激活的体素。结果显示，由于数据平滑，运动中心像差在测量之间增加了约100%，表明定位可重复性在统计学上显著降低。(C)2004年爱思唯尔公司All rights reserved.
Recent publications analyzing the influence of spatial smoothing oil fMRI brain activation results demonstrated that smoothing may artificially combine activations from adjacent though functionally and anatomically distinct brain regions and that activation from large draining vessels may be smoothed into neighboring neuronal tissue. To investigate whether functional localizations may be artificially shifted by the smoothing procedure we performed replicability measurements. Localization centers of motor hand activations achieved during different conditions (isolated hand movements and simultaneous hand and chin movements) were compared with respect to smoothing effects. The voxel with the highest probability to represent a true positive activation was localized with a non-smoothed and a standard 4 x 4 x 6 mm smoothed correlational data analysis technique. Results show an increase of motor center aberrations between measurements by about 100% due to data smoothing indicating a statistically significant decrease in localization replicability. (C) 2004 Elsevier Inc. All rights reserved.