Association study on glutathione S-transferase omega 1 and 2 and familial ALS
Association study on glutathione S-transferase omega 1 and 2 and familial ALS
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DOI：
10.1080/17482960701702553
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发表时间：
2008-04-01
影响因子：
--
通讯作者：
Shaw, Christopher E.
中科院分区：
文献类型：
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作者：
De Giessen, Elsmarieke Van;Fogh, Isabella;Shaw, Christopher E.
谷胱甘肽s -转移酶- 1和- 2 （GSTO1和2）可以防止氧化应激，这可能是神经退行性疾病（如肌萎缩侧索硬化症（ALS）和阿尔茨海默病）发病的致病机制。最近发现，阿尔茨海默病患者的发病年龄与GSTO1和2有显著关联，这表明与ALS可能存在类似的关联。本研究对251例英国、澳大利亚和瑞典白种人家族性ALS （FALS）患者的GSTO1和gsto2基因进行了12个单核苷酸多态性（Hapmap）标记。在英国和澳大利亚的FALS患者中，没有发现发病年龄和生存期之间的关联。在瑞典患者中，发现几个snp与发病年龄相关（p=0.003-0.048）。这些结果提示GSTO1和gsto2位点可能对FALS发病年龄有影响。
Glutathione S-transferase omega 1 and 2 (GSTO1 and 2) protect from oxidative stress, a possible pathogenic mechanism underlying the pathogenesis of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. Significant association of age of onset in Alzheimer's patients with GSTO1 and 2 had recently been identified, suggesting a possibly similar association with ALS. In this study 12 Hapmap tagged SNPs in GSTO1 and 2 were genotyped in 251 Caucasian British, Australian and Swedish familial ALS (FALS) cases. No association was found for age of onset and survival of FALS in the British and Australian patients. In the Swedish patients, association for age of onset was found with several SNPs (p=0.003-0.048). These results suggest a possible effect of the GSTO1 and 2 locus on age of onset of FALS.