Clinical characteristics and prognosis of hepatocellular carcinoma with different sets of serum AFP and PIVKA-II levels
Clinical characteristics and prognosis of hepatocellular carcinoma with different sets of serum AFP and PIVKA-II levels
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DOI：
10.1097/meg.0b013e3283535c34
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发表时间：
2012-07-01
影响因子：
2.1
通讯作者：
Han, Kwang-Hyub
中科院分区：
文献类型：
--
作者：
Kang, Se Hun;Kim, Do Young;Han, Kwang-Hyub
目的甲胎蛋白(AFP)和缺乏维生素K或拮抗剂-II(Pivka-II)诱导的凝血酶原(Pivka-II)是诊断肝细胞癌的有用肿瘤标志物。方法连续1447例肝细胞癌患者，根据AFP(400 ng/ml)和Pivka-II(100MAU/ml)的临界值分为4组：高值(AP)、高值(AP和AP)、低值(AP)。结果AP组肝细胞癌患者确诊时无症状、体积小、个数少、分期早、肝功能保存好(均P<0.05)。
Objective alpha-Fetoprotein (AFP) and prothrombin induced by the absence of vitamin K or antagonist-II (PIVKA-II) are useful tumor markers for hepatocellular carcinoma (HCC). However, little is known about the clinical characteristics and prognosis of HCC with different levels of AFP and PIVKA-II.Methods Consecutive 1447 HCC patients were assigned to four groups according to the cutoff values of AFP (400 ng/ml) and PIVKA-II (100 mAU/ml): both values high (AP), one of the values high (Ap and aP), and both values low (ap). The clinical characteristics and the prognosis of group ap were compared with those of the other groups.Results HCC patients in group ap were more asymptomatic at diagnosis, and had smaller size, fewer numbers, and earlier stages of HCC, and more preserved liver functions (all, P