Post-exercise heart rate recovery in HIV-positive individuals on highly active antiretroviral therapy. Early indicator of cardiovascular disease?
Post-exercise heart rate recovery in HIV-positive individuals on highly active antiretroviral therapy. Early indicator of cardiovascular disease?
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DOI：
10.1111/j.1468-1293.2007.00524.x
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发表时间：
2008-02-01
期刊：
影响因子：
3
通讯作者：
Yarasheski, K. E.
中科院分区：
文献类型：
--
作者：
Cade, W. T.;Reeds, D. N.;Yarasheski, K. E.
背景HIV感染及其治疗，特别是蛋白酶抑制剂(PI)治疗，已被认为与心血管疾病的风险增加有关。在一般人群中，高峰运动后心率恢复(HRR)可以预测未来的心血管事件和死亡率。HIV感染者在接受高效抗逆转录病毒治疗(HAART)时的HRR尚不清楚。受试者和方法接受HAART的HIV阳性受试者包括PI(HIV+PI，n=19)、HAART不包括PI的HIV阳性受试者(HIV+NOPI，n=19)和HIV血清阴性的年龄、性别和体重指数(BMI)匹配的对照组(CNTL，n=15)。结果HIV感染者运动后1.5min和2min的心率均较对照组明显延迟(P<0.05)。
BackgroundHIV infection and its treatment, specifically protease inhibitor (PI) therapy, have been associated with an increased risk for cardiovascular disease. Heart rate recovery (HRR) following peak exercise is predictive of future cardiovascular events and mortality in the general population. Nothing is known regarding HRR in individuals infected with HIV on highly active antiretroviral therapy (HAART).Subjects and methodsHIV-positive subjects on HAART that included a PI (HIV + PI, n = 19), HIV-positive subjects on HAART that did not include a PI (HIV + noPI, n = 19) and HIV-seronegative age, gender and body mass index (BMI) matched controls (Cntl, n = 15) underwent a graded maximal exercise test on a cycle ergometer to volitional exhaustion. A continuous electrocardiogram was recorded and HRR was monitored every 30 s for 2 min post exercise.ResultsHRR at 1.5 and 2 min was significantly delayed in HIV-positive subjects both on and not on PI-based HAART compared with controls (P