A novel method for measuring the bending rigidity of model lipid membranes by simulating tethers
A novel method for measuring the bending rigidity of model lipid membranes by simulating tethers
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DOI：
10.1063/1.2372761
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发表时间：
2006-11-28
影响因子：
4.4
通讯作者：
Deserno, Markus
中科院分区：
文献类型：
--
作者：
Harmandaris, Vagelis A.;Deserno, Markus
沿着圆柱形脂质双层管的张力与膜的弯曲模量成正比，与管半径成反比。我们证明，这种在实验上用于测量弯曲刚度的关系可以更轻松地应用于计算机模拟中。使用粗粒双层模型，我们有效地获得了弯曲刚度，该刚度与基于热波动模式分析的互补测量结果非常好。我们进一步说明，在曲率半径与双层厚度相当的范围内，不会出现与简单二次连续介质理论的偏差。 (c) 2006 年美国物理研究所。
The tensile force along a cylindrical lipid bilayer tube is proportional to the membrane's bending modulus and inversely proportional to the tube radius. We show that this relation, which is experimentally exploited to measure bending rigidities, can be applied with even greater ease in computer simulations. Using a coarse-grained bilayer model we efficiently obtain bending rigidities that compare very well with complementary measurements based on an analysis of thermal undulation modes. We furthermore illustrate that no deviations from simple quadratic continuum theory occur up to a radius of curvature comparable to the bilayer thickness. (c) 2006 American Institute of Physics.