Directed self-assembly of microscale hydrogels by electrostatic interaction
Directed self-assembly of microscale hydrogels by electrostatic interaction
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通过静电相互作用定向自组装微型水凝胶
DOI：
10.1088/1758-5082/5/3/035004
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发表时间：
2013-09-01
期刊：
影响因子：
9
通讯作者：
Xu, Feng
中科院分区：
文献类型：
--
作者：
Han, Yu Long;Yang, Yanshen;Xu, Feng
首次证明了溶液中微尺度组件静电自组装的独特优势。特别是，积极和消极的治疗聚（乙二醇）（PEG）促进了一种新的自下而上的组装方法，使用静电相互作用，从微凝胶与相反的电荷。微凝胶静电相互作用的基础研究表明，微凝胶的接触面积决定了结构的总能量，从而决定了最终的图案。静电自组装方法使得能够制造大而复杂的生物相关结构（例如，多层球体），具有精确的控制。通过微凝胶的设计，可以控制每层中微凝胶的厚度和数量。PEG的阳性和阴性治疗的生物学研究进一步证明了在组织工程、再生医学和药物递送中使用这种方法的可能性。
The unique benefit of electrostatic self-assembly of microscale components in solution is demonstrated for the first time. In particular, positive and negative treatment of poly(ethylene glycol) (PEG) facilitates a novel bottom-up assembly approach using electrostatic interaction from microgels with opposite charges. Fundamental investigations of electrostatic interaction of microgels reveal that the contact area of microgels determines the total energy of construct and thus the final patterns. The electrostatic self-assembly approach enables the fabrication of large and complex biological related structures (e.g., multi-layer spheroid) with accurate control. By the design of the microgels, the thickness and number of microgels in each layer can be controlled. Biological investigations of positive and negative treatments of PEG further prove the possibility of using this approach in tissue engineering, regenerative medicine and drug delivery.