Opinion - The Icelandic Cancer Project - a population-wide approach to studying cancer
Opinion - The Icelandic Cancer Project - a population-wide approach to studying cancer
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DOI：
10.1038/nrc1371
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发表时间：
2004-06-01
影响因子：
78.5
通讯作者：
Thorgeirsson, SS
中科院分区：
文献类型：
--
作者：
Rafnar, T;Thorlacius, S;Thorgeirsson, SS
癌症的发生和发展需要遗传、环境和临床因素的复杂相互作用。然而，大多数研究只集中在疾病过程的一个狭窄方面。人类基因组计划产生的数据以及对肿瘤的大规模分子分析表明，有必要采取更系统的方法，将生物信息与临床特征相结合。冰岛人口的许多方面使其非常适合这种基础广泛的方法。因此，启动了冰岛癌症项目，以建立一个基于人群的临床基因组学数据库和生物库，可用于研究癌症--从遗传易感性到临床结果。
Cancer initiation and progression require a complex interaction of genetic, environmental and clinical factors. Most research, however, has been focused on only a narrow aspect of the disease process. Data generated by the Human Genome Project, as well as large-scale molecular analysis of tumours, have indicated that a more systematic approach, in which the biological information is integrated with clinical features, is warranted. There are many aspects of the Icelandic population that make it well suited for such a broad-based approach. The Icelandic Cancer Project was therefore initiated to build a population-based clinical genomics database and biobank that can be used to study cancer — from genetic predisposition to clinical outcome.