The role of innate immunity in obesity
The role of innate immunity in obesity
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DOI：
10.1590/s0036-36342012000200014
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发表时间：
2012-04-01
期刊：
影响因子：
--
通讯作者：
Cruz, Miguel
中科院分区：
文献类型：
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作者：
Fortis, Ángeles;García-Macedo, Rebeca;Cruz, Miguel
在墨西哥，肥胖症在成人和儿童中的流行率惊人地增加，它是胰岛素抵抗以及其他代谢改变发展的危险因素。Toll样受体（TLR）在脂肪细胞中表达的发现，提示了其在先天免疫中的重要作用。在不同的肥胖模型中，已经观察到脂肪组织中TLR表达的增加，因此TLR可能参与这种疾病的全身性炎症，并参与胰岛素抵抗的发展。TLR的活化由脂肪酸介导，其表达受瘦素、脂联素和PPARs调节。了解TLR在炎症和脂肪细胞分化及其调节中的作用，则重要的是尝试开发有助于治疗肥胖的新的治疗性抗炎靶点。
Obesity in Mexico is alarmingly increasing in prevalence in adults and children, and it is a risk factor for the development of insulin resistance, as well as, of other metabolic alterations. The discovery of the expression of the Toll-like receptors (TLRs) in adipocytes, suggests an important role in innate immunity. In different models of obesity, there has been observed an increase of TLRs expression in the fat tissue, therefore TLRs could be involved in systemic inflammation in this disease, and in the development of insulin resistance. TLR activation is mediated by fatty acids and their expression is regulated by leptin, adiponectin and PPARs. Knowledge of the role of TLRs in inflammation and adipocyte differentiation and their regulation, then it is important to try to develop new therapeutic anti-inflammatory targets that contribute in the treatment of obesity.