Aquaporin 1 (AQP1) expression is a novel characteristic feature of a particularly aggressive subgroup of basal-like breast carcinomas
Aquaporin 1 (AQP1) expression is a novel characteristic feature of a particularly aggressive subgroup of basal-like breast carcinomas
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DOI：
10.1007/s10549-009-0370-9
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发表时间：
2010-02-01
影响因子：
3.8
通讯作者：
Bankfalvi, Agnes
中科院分区：
文献类型：
--
作者：
Otterbach, Friedrich;Callies, Rainer;Bankfalvi, Agnes
水通道蛋白1（AQP1）是一种水通道蛋白，可促进水穿过细胞膜。它广泛表达于多种组织的上皮细胞和内皮细胞中。AQP1还与某些人类恶性肿瘤的血管生成、细胞迁移和转移有关。本研究采用免疫组化法检测了203例浸润性乳腺癌组织中水通道蛋白1的表达情况。AQP1表达在11个肿瘤（5.4%），并显示出高度显着的相关性与高肿瘤分级，髓样组织学，“三阴性”，细胞角蛋白14和平滑肌肌动蛋白表达。在单因素分析中，AQP1与不良预后显著相关。在多变量分析中，AQP1表达被证明是一个独立的预后指标，如果分层的年龄，肿瘤大小，淋巴结状态，组织学分级，ER状态和CMF治疗。我们的研究结果强烈表明，AQP1表达是一个新的特征性的一个特别积极的亚组基底样乳腺癌。
Aquaporin1 (AQP1) is a water channel protein that facilitates water flux across cell membranes. It is widely expressed in epithelial and endothelial cells in several tissues. AQP1 is also associated with angiogenesis, cell migration and metastasis in some human malignancies. In this study the immunohistochemical expression of AQP1 in 203 invasive breast carcinomas with long-term follow up was investigated. AQP1 expression was demonstrated in 11 tumours (5.4%) and showed highly significant correlation with high tumour grade, medullary-like histology, "triple-negativity", cytokeratin 14 and smooth muscle actin expression. In univariate analysis, AQP1 was significantly associated with poor prognosis. In multivariate analysis, AQP1 expression proved to be an independent prognostic marker if stratified by age, tumour size, lymph node status, histological grade, ER status and CMF therapy. Our results strongly suggest that AQP1 expression is a new characteristic feature of a particularly aggressive subgroup of basal-like breast carcinomas.