Database of p53 gene somatic mutations in human tumors and cell lines: Updated compilation and future prospects
Database of p53 gene somatic mutations in human tumors and cell lines: Updated compilation and future prospects
复制标题
DOI：
10.1093/nar/25.1.151
复制
发表时间：
1997-01-01
影响因子：
14.9
通讯作者：
Montesano, R
中科院分区：
文献类型：
--
作者：
Hainaut, P;Soussi, T;Montesano, R
近年来，在人类癌症中鉴定的p53突变的数量呈指数增长。p53突变数据库由人类肿瘤和细胞系的p53基因中的点突变的列表组成，其从已发表的文献中汇编并通过电子媒体提供，该数据库目前由国际癌症研究机构维护，每年更新两次，目前的版本包含5091个已发表的突变记录，预计在1997年1月发布时将超过6000个，该数据库可通过欧洲生物信息学研究所（EBI）ftp服务器（www.example.com）或IARC的请求以各种格式提供ftp://ftp.ebi.ac.uk/pub/databases/p53/。（p53database@iarc.fr），并将在不久的将来通过SRS系统进行搜索。本文综述了p53基因突变分析与临床和生物学问题的相关性，并简要讨论了其未来的发展前景。
In recent years, there has been an exponential increase in the number of p53 mutations identified in human cancers, The p53 mutation database consists of a list of point mutations in the p53 gene of human tumors and cell lines, compiled from the published literature and made available through electronic media, The database is now maintained at the International Agency for Research on Cancer (IARC) and is updated twice a year, The current version contains records on 5091 published mutations and is expected to surpass the 6000 mark in the January 1997 release, The database is available in various formats through the European Bioinformatics Institute (EBI) ftp server at: ftp://ftp.ebi.ac.uk/pub/databases/p53/ or by request from IARC (p53database@iarc.fr) and will be searchable through the SRS system in the near future, This report provides a description of the criteria for inclusion of data and of the current formats, a summary of the relevance of p53 mutation analysis to clinical and biological questions, and a brief discussion of the prospects for future developments.