Glomerular hypertension, abnormal glomerular growth, and progression of renal diseases
Glomerular hypertension, abnormal glomerular growth, and progression of renal diseases
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DOI：
10.1046/j.1523-1755.2000.07505.x
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发表时间：
2000-04-01
影响因子：
19.6
通讯作者：
Fogo, AB
中科院分区：
文献类型：
--
作者：
Fogo, AB
硬化的发展和进展是由许多机制的复杂相互作用决定的，包括直接的血液动力学作用、肾小球细胞损伤的调节和生长因子作用。这些因素的相互作用决定了细胞生长和增殖相对于通过坏死或凋亡的细胞死亡的平衡。以及基质积累与降解的平衡。当治疗通过直接增加蛋白水解活性和下调基质降解抑制剂来抑制这些机制并增加基质降解过程时，硬化甚至可以逆转。我们将集中在这方面的作用，肾小球血流动力学和生长的肾脏疾病的进展。
The development and progression of sclerosis is determined by complex interactions of many mechanisms, including direct hemodynamic actions, modulation of glomerular cell injury, and growth factor actions. The interplay of these factors determines the balance of cell growth and proliferation versus cell death by necrosis or apoptosis. and the balance of matrix accumulation versus degradation. Sclerosis may even be reversed when therapies inhibit these mechanisms and augment matrix degradation processes, both by directly increasing proteolytic activity and by down-regulating inhibitors of matrix degradation. We will focus in this review on the roles of glomerular hemodynamics and growth in the progression of renal diseases.